Reactome | Rplp0 [cytosol]

Rplp0 [cytosol]

Stable Identifier

R-MMU-9633527

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

60S acidic ribosomal protein P0, RLA0_MOUSE

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rplp0 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P14869 Rplp0

Gene Names

Rplp0, Arbp

Chain

chain:1-317

Reference Genes

BioGPS Gene:11837 Rplp0

ENSEMBL:ENSMUSG00000067274.11 Rplp0

KEGG Gene (Mus musculus):11837 Rplp0

Monarch:11837 Rplp0

NCBI Gene:11837 Rplp0

UCSC:P14869 Rplp0

Reference Transcript

RefSeq:NM_007475.5 Rplp0

Other Identifiers

101213_at

10405935

10436694

10524718

10581027

11837

1419441_at

166005_f_at

17441191

17512171

4307509

4309080

4369920

4385715

4402258

4482889

4522941

4551704

4617450

4720245

4804570

4848727

4965910

4994266

5016535

5178278

5243003

5262292

5386995

5390295

5482980

5522134

A_51_P134602

A_66_P105288

C76057_rc_f_at

GE33429

GO:0000027

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005634

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0007595

GO:0010269

GO:0014069

GO:0022625

GO:0022626

GO:0030425

GO:0036464

GO:0042254

GO:0042277

GO:0043226

GO:0045202

GO:0048856

GO:0065003

GO:0070180

GO:0071320

GO:0071353

GO:0098794

GO:1904401

GO:1904628

GO:1990904

ILMN_1249815

ILMN_2744356

Msa.2162.0_f_at

X15267_f_at

mMC013809

Participates

as a component of

Inferred From

RPLP0 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_031501.1

Ensembl

ENSMUSG00000067274, ENSMUST00000086519, ENSMUSP00000083705

PRO

P14869

MGI

1927636

PDB

7LS2, 7LS1

Cite Us!