Cat gene expression is stimulated by Foxo3

Stable Identifier
R-MMU-9622815
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cat gene expression is stimulated by Foxo3
In mouse granulosa cells (Song et al. 2016), as well as microglial cells (Rangarajan et al. 2015), endogenous Foxo3 directly stimulates transcription of the Cat gene, encoding catalase.
Literature References
PubMed ID Title Journal Year
27731402 Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice

Song, C, Peng, W, Yin, S, Zhao, J, Fu, B, Zhang, J, Mao, T, Wu, H, Zhang, Y

Sci Rep 2016
26523980 Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia

Rangarajan, P, Karthikeyan, A, Lu, J, Ling, EA, Dheen, ST

Neuroscience 2015
Participants
Input
Output
This event is regulated
Positively by
Regulator
Foxo3:Cat gene [nucleoplasm] (Mus musculus)
Active Unit
Foxo3 [nucleoplasm]
Orthologous Events
CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1) (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-10-01)
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