Reactome | Rps6ka3 [nucleoplasm]

Rps6ka3 [nucleoplasm]

Stable Identifier

R-MMU-9620028

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Rsk2

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular Senescence (Mus musculus)
    - Senescence-Associated Secretory Phenotype (SASP) (Mus musculus)
      - ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (q) signalling events (Mus musculus)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by NTRKs (Mus musculus)
    - Signaling by NTRK1 (TRKA) (Mus musculus)
      - Nuclear Events (kinase and transcription factor activation) (Mus musculus)
        
        ERK/MAPK targets (Mus musculus)
        
        ERK1/2/5 activate RSK1/2/3 (Mus musculus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)
        
        Rps6ka3 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P18654 Rps6ka3

Gene Names

Rps6ka3, Mapkapk1b, Rps6ka-rs1, Rsk2

Chain

chain:1-740

Reference Genes

BioGPS Gene:110651 Rps6ka3

KEGG:mmu:110651 Rps6ka3

Monarch:110651 Rps6ka3

NCBI Gene:110651 Rps6ka3

UCSC:P18654 Rps6ka3

Reference Transcript

RefSeq:NM_148945.2 Rps6ka3

Other Identifiers

10602772

110651

132772_at

136147_r_at

1427299_at

1452383_at

1455206_at

17539125

4343935

4450304

4488517

4536177

4540649

4553595

4557139

4601671

4606489

4642299

4649370

4678412

4688299

4720062

4725163

4740122

4745415

4766516

4899727

4923620

4962261

4972316

5000388

5003437

5006514

5011894

5088194

5092530

5099053

5107619

5115004

5143435

5149264

5149270

5150918

5221163

5221520

5264120

5300846

5313691

5340353

5355484

5356620

5363005

5366745

5367264

5373330

5427306

5435427

5448089

5499506

5532177

5545072

5548593

5549086

5567050

5572077

5599281

5600819

A_52_P283628

A_52_P75975

A_55_P1952981

A_55_P1952985

A_55_P2404434

GE136378

GO:0000166

GO:0000287

GO:0002224

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004711

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0016301

GO:0016740

GO:0019901

GO:0032496

GO:0035556

GO:0038202

GO:0043066

GO:0045944

GO:0106310

GO:0140096

ILMN_1247009

ILMN_2505442

ILMN_2731080

Msa.6343.0_s_at

aa175340_s_at

mMC007499

mMC010680

Participates

as a member of

Ribosomal protein S6 kinase [nucleoplasm] (Mus musculus)

as an input of

PDPK1 phosphorylates Rps6ka2 (Homo sapiens)

Other forms of this molecule

phospho-p-4S,T231,T365-RPS6KA3 [nucleoplasm]

p-S227-Rps6ka3 [nucleoplasm]

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]

phospho-p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]

Inferred From

RPS6KA3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_683747.1

ENSEMBL

ENSMUSG00000031309, ENSMUSP00000033671, ENSMUST00000033671

PRO

P18654

GlyGen

P18654

MGI

104557

PDB

4GUE, 2QR8, 2QR7, 3G51, 4EL9, 5O1S, 4MAO, 4M8T, 3UBD

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P97879	2	Grip1 [plasma membrane] (R-RNO-416638) Grip1 [cytosol] (R-RNO-416633)	0.581	3
UniProt:Q9WV48 Shank1	2	Shank1 [cytosol] (R-RNO-6794229) Shank1 [cytosol] (R-RNO-6794274)	0.508	2
UniProt:Q4L1J4 MAGI1			0.508	2
UniProt:Q9JLU4 Shank3	2	Shank3 [cytosol] (R-RNO-6794258) Shank3 [cytosol] (R-RNO-6794277)	0.508	2
UniProt:P28223-1 HTR2A			0.508	2
UniProt:P35438 Grin1	3	Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.462	2

Cite Us!