Plins:Hspa8 binds Prkaa2

Stable Identifier
R-MMU-9613507
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, lipid droplet
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Plins:Hspa8 binds Prkaa2
Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. Lipid droplets are coated with perilipin (Plin) protiens and they need to be eliminated for the degradation of the lipids inside. Cytosolic Heat shock cognate 71 kDa protein (Hspa8) binds Plin2 and Plin3 on the lipid droplet surface. Consequently, Prkaa2 bind and phosphorylate perilipins targeting them for lipophagy (S Kaushik et al. 2015, S Kaushik et al. 2016).
Literature References
Participants
Input
Output
Orthologous Events
PLINs:HSPA8 binds PRKAA2 (Homo sapiens)
Authored
Varusai, TM  (2019-11-08)
Reviewed
Metzakopian, E  (2019-02-22)
Created
Varusai, TM  (2018-07-16)
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