Reactome | EIF4A3 [cytosol]

EIF4A3 [cytosol]

Stable Identifier

R-MMU-927868

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

Q91VC3

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Deadenylation-dependent mRNA decay (Mus musculus)
  - Deadenylation of mRNA (Mus musculus)
    - CCR4-NOT complex deadenylates mRNA (Mus musculus)
      - Partially Deadenylated mRNA Complex [cytosol] (Mus musculus)
        
        eIF4A [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
      - eIF4A [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
    - PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)
      - Partially Deadenylated mRNA Complex [cytosol] (Mus musculus)
        
        eIF4A [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
      - Translatable mRNA Complex [cytosol] (Mus musculus)
        
        eIF4A [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
    - PARN deadenylates mRNA (Mus musculus)
      - Partially Deadenylated mRNA Complex [cytosol] (Mus musculus)
        
        eIF4A [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
      - eIF4A [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - Transport of Mature Transcript to Cytoplasm (Mus musculus)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Mus musculus)
      - Transport of the export-competent mRNP complex through the NPC (Mus musculus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
      - mRNP complex dissociates from cytosolic face of NPC (Mus musculus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Mus musculus)
        
        EJC [cytosol] (Mus musculus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)
        
        EIF4A3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91VC3

Reference Genes

BioGPS Gene:192170

ENSEMBL:ENSMUSG00000025580

KEGG:mmu:192170

Monarch:192170

NCBI Gene:192170

UCSC:Q91VC3

Reference Transcript

RefSeq:NM_138669.1

Other Identifiers

101485_at

10393642

10539177

10541067

1417242_at

17272895

17548520

192170

4311805

4384034

4450221

4464885

4492868

4606629

4618680

4662209

4712960

4727773

4734650

4780294

4786403

4838306

5092893

5154723

5204640

5249584

5261726

5278801

5296910

5388812

5471967

5492514

5569943

A_52_P67995

GE128997

GO:0000166

GO:0000184

GO:0000381

GO:0000398

GO:0003676

GO:0003723

GO:0003724

GO:0003729

GO:0003824

GO:0004386

GO:0005524

GO:0005634

GO:0005681

GO:0005730

GO:0005737

GO:0006355

GO:0006364

GO:0006397

GO:0006406

GO:0006417

GO:0006913

GO:0008380

GO:0016071

GO:0016607

GO:0016787

GO:0016887

GO:0035145

GO:0045944

GO:0048026

GO:0048701

GO:0051028

GO:0071006

GO:0071013

GO:0140098

GO:0140657

GO:2000622

ILMN_2588254

Msa.9866.0_s_at

mMC022795

Participates

as a component of

Core Exon Junction Complex (Core EJC) [cytosol] (Mus musculus)

as a member of

eIF4A [cytosol] (Mus musculus)

Other forms of this molecule

EIF4A3 [nucleoplasm]

Inferred From

EIF4A3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_619610.1

ENSEMBL

ENSMUSP00000026667, ENSMUST00000026667, ENSMUSG00000025580

PRO

Q91VC3

GlyGen

Q91VC3

MGI

1923731

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