Inhibition of Jak kinase activity by Socs1/3

Stable Identifier
R-MMU-912695
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Inhibition of Jak kinase activity by Socs1/3
SOCS1/3 are the major negative regulators of IFNA/B signaling. They inhibit JAKs catalytic activity directly through their kinase inhibitory region (KIR) and turn off downstream IFNA/B signaling. SOCS1 may also prevent IFN signaling by targeting the signaling machinery to ubiquitin-proteasomal degradation pathway.
Literature References
PubMed ID Title Journal Year
16311601 Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

Alexander, WS, Schreiber, RD, Sheehan, K, Fenner, JE, Starr, R, Metcalf, D, Cornish, AL, Hertzog, PJ, Hilton, DJ, Zhang, JG

Nat Immunol 2006
Participants
Input
Output
Orthologous Events
Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)
Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-07-12)
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