Reactome | ATP6V1B2 [cytosol]

ATP6V1B2 [cytosol]

Stable Identifier

R-MMU-912598

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P62814

Locations in the PathwayBrowser

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Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to starvation (Mus musculus)
    - Amino acids regulate mTORC1 (Mus musculus)
      - RRAGA,B exchanges GDP for GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - RRAGA,B hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - RRAGC,D exchanges GTP for GDP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - RRAGC,D hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - mTORC1 binds RHEB:GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        v-ATPase [lysosomal membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - ROS and RNS production in phagocytes (Mus musculus)
    - Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)
      - V-ATPase [phagocytic vesicle membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by Insulin receptor (Mus musculus)
    - Insulin receptor recycling (Mus musculus)
      - ATP6AP1 binds V-ATPase (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - Endosome acidification (Mus musculus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)

Transport of small molecules (Mus musculus)

- Ion channel transport (Mus musculus)
  - ATP6AP1 binds V-ATPase (Mus musculus)
    - V-ATPase [endosome membrane] (Mus musculus)
      - ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
      - V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
- Iron uptake and transport (Mus musculus)
  - Transferrin endocytosis and recycling (Mus musculus)
    - ATP6AP1 binds V-ATPase (Mus musculus)
      - V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)
    - Acidification of Tf:TfR1 containing endosome (Mus musculus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Mus musculus)
        
        V-ATPase [endosome membrane] (Mus musculus)
        
        ATP6V1 [cytosol] (Mus musculus)
        
        ATP6V1B trimer [cytosol] (Mus musculus)
        
        ATP6V1B [cytosol] (Mus musculus)
        
        ATP6V1B2 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P62814

Reference Genes

BioGPS Gene:11966

ENSEMBL:ENSMUSG00000006273

KEGG:mmu:11966

Monarch:11966

NCBI Gene:11966

UCSC:P62814

Reference Transcript

RefSeq:NM_007509.3

Other Identifiers

10572146

11966

131277_at

138577_at

1415814_at

1419883_s_at

17501652

4305491

4368709

4372338

4461957

4571432

4587288

4590688

4631538

4703483

4714364

4716595

4732834

4755499

4868381

4941065

4967488

5189448

5211043

5262589

5274725

5305020

5384413

5410084

5414294

5437987

5442833

5481396

5515062

5526433

92597_s_at

92598_at

A_51_P190845

A_55_P2938687

GE34771

GO:0000166

GO:0000221

GO:0001726

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005902

GO:0006811

GO:0007035

GO:0016020

GO:0016324

GO:0030665

GO:0030672

GO:0031410

GO:0033180

GO:0042470

GO:0043209

GO:0045202

GO:0046034

GO:0046961

GO:0055085

GO:0055086

GO:0097401

GO:0098850

GO:1901135

GO:1902600

ILMN_2680440

Msa.1868.0_s_at

mMC003864

Participates

as a member of

ATP6V1B [cytosol] (Mus musculus)

Inferred From

ATP6V1B2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_031535.2

ENSEMBL

ENSMUSP00000006435, ENSMUST00000006435, ENSMUSG00000006273

PRO

P62814

GlyGen

P62814

MGI

109618

PDB

9BRU, 9BRS, 9BRA, 9BRT, 9BRQ, 9BRR

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