Recruitment of Brca1 to Unsynapsed Regions

Stable Identifier
R-MMU-912468
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of Brca1 to Unsynapsed Regions
Unsynapsed regions of chromosomes are silenced during pachytene by a process called Meiotic Silencing of Unsynapsed Chromatin (MSUC) and, in the case of the X and Y chromosomes, Meiotic Sex Chromosome Inactivation (MSCI). Unsynapsed meiotic chromatin recruits Brca11 (Turner et al. 2004, Turner et al. 2005, Mahadevaiah et al. 2008, Kouznetsova et al. 2009). The recruitment requires Sycp3 of axial elements of the synaptonemal complex, which may remain exposed in unsynapsed regions (Kouznetsova et al. 2009).
Literature References
PubMed ID Title Journal Year
15589157 BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation

Turner, JM, Aprelikova, O, Xu, X, Wang, R, Kim, S, Chandramouli, GV, Barrett, JC, Burgoyne, PS, Deng, CX

Curr Biol 2004
15580272 Silencing of unsynapsed meiotic chromosomes in the mouse

Turner, JM, Mahadevaiah, SK, Fernandez-Capetillo, O, Nussenzweig, A, Xu, X, Deng, CX, Burgoyne, PS

Nat Genet 2005
18663141 Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

Mahadevaiah, SK, Bourc'his, D, de Rooij, DG, Bestor, TH, Turner, JM, Burgoyne, PS

J Cell Biol 2008
19531582 BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes

Kouznetsova, A, Wang, H, Bellani, M, Camerini-Otero, RD, Jessberger, R, Höög, C

J Cell Sci 2009
Participants
Input
Output
Orthologous Events
BRCA1 is recruited to unsynapsed regions (Homo sapiens)
Authored
May, B  (2010-07-03)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Holloway, JK  (2011-02-05)
Lyndaker, A  (2011-02-25)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Created
May, B  (2010-07-09)
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