Formation of Meiotic Holliday Junction

Stable Identifier
R-MMU-912462
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of Meiotic Holliday Junction
The 3' end of the invading strand is extended by an unknown DNA polymerase and the extended strand is then ligated back to the original homolog, generating a double Holliday junction. Msh4 and Msh5 form heterodimers which bind Holliday junctions and, in the presence of ATP, slide along the duplexes (de Vries et al. 1999, Her et al. 2001). Msh4 is present at hundreds of meiotic nodules during late zygotene but only about 10% of these nodules become mature crossovers (Plug et al. 1998, Kneitz et al. 2000, Moens et al. 2002, de Boer et al. 2006, Moens et al. 2007). Bloom Syndrome protein (BLM) and Topoisomerase IIIa (TOP3A) are also present and may promote homologous recombination repair without crossing over (Walpita et al. 1999, Moens et al. 2000, Moens et al. 2007).
Literature References
PubMed ID Title Journal Year
10318934 Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes

Walpita, D, Plug, AW, German, J, Ashley, T, Neff, NF

Proc Natl Acad Sci U S A 1999
11950880 The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination

Kolas, NK, Marcon, E, Cohen, PE, Moens, PB, Spyropoulos, B, Tarsounas, M

J Cell Sci 2002
11178747 Mouse MutS homolog 4 is predominantly expressed in testis and interacts with MutS homolog 5

Bailey, SM, Doggett, NA, Her, C, Wu, X

Mamm Genome 2001
10652259 Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom's syndrome, suggest a role in recombination during meiotic prophase

Jackson, SP, Freire, R, Moens, PB, Spyropoulos, B, Tarsounas, M

J Cell Sci 2000
10072381 Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis

te Riele, H, de Rooij, DG, de Boer, P, Baart, EB, Siezen, A, Dekker, M, de Vries, SS

Genes Dev 1999
9443891 Changes in protein composition of meiotic nodules during mammalian meiosis

Keegan, KS, Plug, AW, de Boer, P, Hoekstra, MF, Ashley, T, Peters, AH

J Cell Sci 1998
17344431 Initiation and resolution of interhomolog connections: crossover and non-crossover sites along mouse synaptonemal complexes

Marcon, E, Kochakpour, N, Shore, JS, Moens, PB, Spyropoulos, B

J Cell Sci 2007
10809667 MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice

Kane, MF, Edelmann, W, Kolodner, RD, Avdievich, E, Zhu, L, Hou H, Jr, Pollard, JW, Kneitz, B, Kucherlapati, R, Cohen, PE

Genes Dev 2000
16766662 Two levels of interference in mouse meiotic recombination

de Boer, E, Heyting, C, Stam, P, Pastink, A, Dietrich, AJ

Proc Natl Acad Sci U S A 2006
Participants
Input
Output
Orthologous Events
Formation of meiotic holliday junction (Homo sapiens)
Authored
May, B  (2010-07-03)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Lyndaker, A  (2011-02-25)
Holloway, JK  (2011-02-05)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Created
May, B  (2010-07-09)
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