Formation of Axial/Lateral Elements of Synaptonemal Complex

Stable Identifier
R-MMU-912362
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of Axial/Lateral Elements of Synaptonemal Complex
Axial elements begin assembling as short linear segments along the long axis of the chromosome in leptotene phase. Eventually the short segments will fuse to form the complete axial element. After synapsis the axial elements are also known as lateral elements of the synaptonemal complex. Within axial elements the sister chromatids are bound together by meiotic cohesin (Pezzi et al. 2000, Prieto et al. 2001, Pelttari et al. 2001, Lee et al. 2003, Prieto et al. 2004, Xu et al. 2004, Parra et al. 2004, James et al. 2002, . The bound chromatids are anchored to a complex containing Sycp2 and Sycp3 via a direct or indirect interaction with cohesin (Yuan et al. 2000, Liebe et al. 2004, Yang et al. 2006) .
Literature References
PubMed ID Title Journal Year
15031719 A new role for the mitotic RAD21/SCC1 cohesin in meiotic chromosome cohesion and segregation in the mouse

Xu, H, Beasley, M, McKay, MJ, Verschoor, S, Handel, MA, Inselman, A

EMBO Rep 2004
15125634 Cohesin component dynamics during meiotic prophase I in mammalian oocytes

Barbero, JL, Hultén, MA, Martinez, A, Buesa, JM, Ortega, S, Kremer, L, Tease, C, Prieto, I, Martinez-A, C, Pezzi, N

Chromosome Res 2004
14970259 Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I

Suja, JA, Gómez, R, Benavente, R, Parra, MT, Rufas, JS, Santos, JL, Page, J, Viera, A

J Cell Sci 2004
12759374 Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis

Iwai, T, Yokota, T, Yamashita, M, Lee, J

J Cell Sci 2003
10678170 The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility

Zhao, J, Liu, JG, Daneholt, B, Höög, C, Yuan, L, Brundell, E

Mol Cell 2000
16717126 Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis

Wang, PJ, McLaughlin, KJ, Leu, NA, Baumann, C, De La Fuente, R, Yang, F

J Cell Biol 2006
14657244 Telomere attachment, meiotic chromosome condensation, pairing, and bouquet stage duration are modified in spermatocytes lacking axial elements

Liebe, B, Benavente, R, Alsheimer, M, Scherthan, H, Höög, C

Mol Biol Cell 2004
11463847 A meiotic chromosomal core consisting of cohesin complex proteins recruits DNA recombination proteins and promotes synapsis in the absence of an axial element in mammalian meiotic cells

Barbero, JL, Moens, P, Liu, JG, Pelttari, J, Santucci-Darmanin, S, Heyting, C, Jessberger, R, Hoja, MR, Höög, C, Yuan, L, Brundell, E

Mol Cell Biol 2001
11483963 Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I

Barbero, JL, Suja, JA, Kremer, L, Prieto, I, Rufas, JS, Martinez-A, C, Pezzi, N

Nat Cell Biol 2001
10698974 STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion

Barbero, JL, Del Mazo, J, Kremer, L, Prieto, I, Martinez-A, C, Valero, C, Pérez Jurado, LA, Pezzi, N

FASEB J 2000
12498344 Differential association of SMC1alpha and SMC3 proteins with meiotic chromosomes in wild-type and SPO11-deficient male mice

Yokomori, K, Schmiesing, JA, James, RD, Disteche, CM, Peters, AH

Chromosome Res 2002
Participants
Input
Output
Orthologous Events
Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)
Authored
May, B  (2010-07-03)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Lyndaker, A  (2011-02-25)
Holloway, JK  (2011-02-05)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Created
May, B  (2010-07-09)
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