Mecp2:Sin3a complex binds Oprm1 gene promoter

Stable Identifier
R-MMU-9017958
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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PNG
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Medium
High
 | PPTX  | SBGN
Mecp2:Sin3a complex binds Oprm1 gene promoter
Endogenous mouse Mecp2 binds to the promoter of the endogenous mouse Oprm1 gene, encoding Mu-type opioid receptor (Hwang et al. 2009, Hwang et al. 2010, Vucetic et al. 2011, Samaco et al. 2012). The endogenous mouse Sin3a co-repressor complex binds to the promoter region of the hypermethylated mouse Oprm1 gene together with Mecp2 (Hwang et al. 2009, Hwang et al. 2010).
Literature References
PubMed ID Title Journal Year
22231481 Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

Samaco, RC, Mandel-Brehm, C, McGraw, CM, Shaw, CA, McGill, BE, Zoghbi, HY

Nat. Genet. 2012
19602036 Epigenetic programming of mu-opioid receptor gene in mouse brain is regulated by MeCP2 and Brg1 chromatin remodelling factor

Hwang, CK, Song, KY, Kim, CS, Choi, HS, Guo, XH, Law, PY, Wei, LN, Loh, HH

J. Cell. Mol. Med. 2009
21326195 Chronic high-fat diet drives postnatal epigenetic regulation of μ-opioid receptor in the brain

Vucetic, Z, Kimmel, J, Reyes, TM

Neuropsychopharmacology 2011
20385708 Up-regulation of the mu-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells

Hwang, CK, Kim, CS, Kim, DK, Law, PY, Wei, LN, Loh, HH

Mol. Pharmacol. 2010
Participants
Input
Output
Orthologous Events
MECP2:SIN3A complex binds OPRM1 gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Christodoulou, J  (2018-08-07)
Krishnaraj, R  (2018-08-07)
Created
Orlic-Milacic, M  (2017-08-28)
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