Isl1 binds the Slit2 gene enhancer

Stable Identifier
R-MMU-9010548
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Isl1 binds the Slit2 gene enhancer
In mice, the transcription factor Isl1, in complex with either Lhx3 or Lhx4, binds to an evolutionarily conserved LIM-HD binding site in the enhancer of the Slit2 gene, located in the sixth intron of the Slit2 gene (Kim et al. 2016). From the previous structural studies of the Isl1 complex with Lhx3, conducted using rat Isl1 (100% sequence identity with mouse Isl1) and mouse Lhx3 and Ldb1, it is known that Ldb1 is also part of the complex of Isl1 and Lhx proteins (Thaler et al. 2002).
Literature References
PubMed ID Title Journal Year
27819291 ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons

Kim, KT, Kim, N, Kim, HK, Lee, H, Gruner, HN, Gergics, P, Park, C, Mastick, GS, Park, HC, Song, MR

Sci Rep 2016
12150931 LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions

Thaler, JP, Lee, SK, Jurata, LW, Gill, GN, Pfaff, SL

Cell 2002
Participants
Input
Output
Orthologous Events
ISL1 binds the SLIT2 gene enhancer (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-27)
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