Reactome | Psmb3 [nucleoplasm]

Psmb3 [nucleoplasm]

Stable Identifier

R-MMU-9008776

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Proteasome subunit beta-3, PSB3_MOUSE

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb3 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb3 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb3 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb3 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb3 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb3 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb3 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb3 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9R1P1 Psmb3

Gene Names

Psmb3

Chain

initiator methionine:1, chain:2-205

Reference Genes

BioGPS Gene:26446 Psmb3

KEGG:mmu:26446 Psmb3

Monarch:26446 Psmb3

NCBI Gene:26446 Psmb3

UCSC:Q9R1P1 Psmb3

Reference Transcript

RefSeq:NM_011971.4 Psmb3

Other Identifiers

10380815

10434643

1417052_at

1460198_a_at

17255862

26446

4319477

4333758

4337227

4396359

4582059

4583835

4727010

4856038

4862059

4948232

4996102

5006817

5090048

5128173

5179906

5304533

5393238

5473250

5481050

5523751

5583274

5597012

5617344

94025_at

AA407689_rc_s_at

A_51_P209193

A_52_P9437

A_55_P2492068

GE35953

GO:0000502

GO:0004175

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0019774

GO:0030163

GO:0043161

GO:0051603

ILMN_1235121

ILMN_2430164

ILMN_2708599

c76949_rc_s_at

mMC013379

mMC019810

Participates

as a component of

Other forms of this molecule

Psmb3 [cytosol]

Inferred From

PSMB3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_036101.1

ENSEMBL

ENSMUST00000103147, ENSMUSP00000099436, ENSMUSG00000069744

PRO

Q9R1P1

MGI

1347014

PDB

3UNH, 8YPK, 3UNF, 3UNB, 8YVP, 3UNE

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