Reactome | Psmb2 [nucleoplasm]

Psmb2 [nucleoplasm]

Stable Identifier

R-MMU-9008767

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Proteasome subunit beta-4, PSB2_MOUSE

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb2 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb2 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb2 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb2 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb2 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb2 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb2 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        20S core particle [nucleoplasm] (Mus musculus)
        
        20S CP inner ring [nucleoplasm] (Mus musculus)
        
        Psmb2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9R1P3 Psmb2

Gene Names

Psmb2

Chain

chain:1-201

Reference Genes

BioGPS Gene:26445 Psmb2

KEGG:mmu:26445 Psmb2

Monarch:26445 Psmb2

NCBI Gene:26445 Psmb2

UCSC:Q9R1P3 Psmb2

Reference Transcript

RefSeq:NM_011970.4 Psmb2

Other Identifiers

10508182

1448262_at

17418629

26445

4428017

4616654

4657763

4686279

4835191

4918166

4998641

5086493

5288831

5304687

5332891

5500948

94219_at

A_51_P404084

A_55_P2922574

GE119600

GO:0000502

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0010498

GO:0019774

GO:0030163

GO:0043161

GO:0051603

ILMN_1256313

ILMN_2765890

ILMN_2949632

ILMN_2949639

aa683747_s_at

mMC015839

Participates

as a component of

Other forms of this molecule

Psmb2 [cytosol]

Inferred From

PSMB2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_036100.3

ENSEMBL

ENSMUST00000030642, ENSMUSG00000028837, ENSMUSP00000030642

PRO

Q9R1P3

MGI

1347045

PDB

3UNH, 8YPK, 3UNF, 3UNB, 8YVP, 3UNE

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