Cdk5:p25 phosphorylates Prdx1

Stable Identifier
R-MMU-8868583
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
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PNG
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Medium
High
 | PPTX  | SBGN
Cdk5:p25 phosphorylates Prdx1
In mouse neurons, Cdk5, aberrantly activated by binding to p25, inactivates peroxide reductase Prdx1 by phosphorylating a conserved threonine residue T90 of Prdx1, which contributes to accumulation of reactive oxygen species (ROS) (Sun et al. 2008).
Literature References
PubMed ID Title Journal Year
18691386 Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

Sun, KH, Vincent, F, Shah, K, de Pablo, Y

J. Neurochem. 2008
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Cdk5:p25 [cytosol]

Physical Entity
Cdk5:p25 [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CDK5:p25 phosphorylates PRDX1 (Homo sapiens)
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-04-22)
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