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phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
Stable Identifier
R-MMU-8864019
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
Q01279
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
EGFR downregulation (Mus musculus)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Mus musculus)
EGF:p-EGFR dimer dephosphorylated at Y1172 (Y1148) [plasma membrane] (Mus musculus)
EGF:p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Mus musculus)
phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Mus musculus)
Signaling by ERBB2 (Mus musculus)
Downregulation of ERBB2 signaling (Mus musculus)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Mus musculus)
Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Mus musculus)
Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Mus musculus)
EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Mus musculus)
EGF:p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Mus musculus)
phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Mus musculus)
Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Mus musculus)
EGF:p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Mus musculus)
EGF:p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Mus musculus)
phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:Q01279
Reference Genes
BioGPS Gene:13649
ENSEMBL:ENSMUSG00000020122
ENSEMBL:ENSMUSG00000020122.17
KEGG Gene (Mus musculus):13649
Monarch:13649
NCBI Gene:13649
UCSC:Q01279
Reference Transcript
RefSeq:NM_207655.2
Other Identifiers
101840_at
101842_g_at
10374366
111476_at
13649
1424932_at
1435888_at
1451530_at
1460420_a_at
17247389
4313293
4313484
4439061
4439225
4494295
4556656
4604756
4651448
4652752
4678149
4702457
4764155
4783608
4862317
4907276
4918092
4941001
4947680
4969923
4999638
5016015
5107778
5128097
5152538
5163125
5191818
5219264
5280032
5315383
5321676
5405997
5409077
5498879
5599345
5604103
5604217
A_52_P106259
A_52_P175190
A_52_P56471
A_52_P674338
A_55_P1956863
GE1417600
GE34995
GO:0000139
GO:0000166
GO:0000278
GO:0000902
GO:0001889
GO:0001892
GO:0001934
GO:0001942
GO:0003013
GO:0003682
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0004888
GO:0005006
GO:0005102
GO:0005178
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006260
GO:0006281
GO:0006351
GO:0006355
GO:0006412
GO:0006468
GO:0006629
GO:0006954
GO:0006979
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007173
GO:0007399
GO:0007435
GO:0007494
GO:0007611
GO:0007623
GO:0008092
GO:0008283
GO:0008284
GO:0008544
GO:0009925
GO:0009986
GO:0010008
GO:0010750
GO:0012501
GO:0014070
GO:0016020
GO:0016101
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0019899
GO:0019900
GO:0019901
GO:0019903
GO:0021795
GO:0022008
GO:0022414
GO:0023052
GO:0030054
GO:0030139
GO:0030154
GO:0030163
GO:0030235
GO:0030296
GO:0030297
GO:0030307
GO:0030324
GO:0030335
GO:0031410
GO:0031625
GO:0031901
GO:0031965
GO:0032355
GO:0032587
GO:0032930
GO:0032991
GO:0033138
GO:0033590
GO:0033594
GO:0033993
GO:0034614
GO:0035556
GO:0036211
GO:0038127
GO:0038134
GO:0042059
GO:0042127
GO:0042177
GO:0042311
GO:0042327
GO:0042698
GO:0042743
GO:0042802
GO:0043066
GO:0043226
GO:0043235
GO:0043410
GO:0043586
GO:0044877
GO:0045121
GO:0045739
GO:0045740
GO:0045780
GO:0045893
GO:0045907
GO:0045930
GO:0045944
GO:0046328
GO:0048143
GO:0048146
GO:0048408
GO:0048471
GO:0048546
GO:0048661
GO:0048812
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050730
GO:0050877
GO:0051015
GO:0051592
GO:0051896
GO:0051897
GO:0051968
GO:0060089
GO:0060252
GO:0060571
GO:0061029
GO:0070141
GO:0070257
GO:0070372
GO:0070374
GO:0071230
GO:0071260
GO:0071276
GO:0071363
GO:0071364
GO:0071392
GO:0071466
GO:0071549
GO:0072659
GO:0090263
GO:0097421
GO:0097489
GO:0097708
GO:0098590
GO:0098609
GO:0098772
GO:0140096
GO:1900087
GO:1901224
GO:1902722
GO:1902895
GO:1902966
GO:1903078
GO:1905208
ILMN_1241496
ILMN_1242210
ILMN_2614432
ILMN_2693922
ILMN_3128725
Msa.231.0_at
mMC013593
mMC016646
Participates
as a component of
EGF:p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
phospho-p-4Y-EGFR [plasma membrane]
EGFR [plasma membrane]
phospho-p-Y1086,Y1101-EGFR [plasma membrane]
phospho-p-6Y-EGFR [plasma membrane]
Inferred From
p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1016 (in Homo sapiens)
Coordinate
1016
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1069 (in Homo sapiens)
Coordinate
1069
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1092 (in Homo sapiens)
Coordinate
1092
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1110 (in Homo sapiens)
Coordinate
1110
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1197 (in Homo sapiens)
Coordinate
1197
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_997538.1
IntEnz
2.7.10.1
ZINC - Substances
EGFR_MOUSE
ZINC target
Q01279
Ensembl
ENSMUSG00000020122
,
ENSMUST00000020329
,
ENSMUSP00000020329
PRO
Q01279
ZINC - Predictions - Purchasable
EGFR_MOUSE
MGI
95294
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.524
2
UniProt:P22682 Cbl
8
Cbl [cytosol]
(R-MMU-9680636)
p-Y-Cbl [cytosol]
(R-MMU-9680645)
phospho-p-Y371-CBL [plasma membrane]
(R-MMU-182923)
phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-MMU-8848826)
phospho-p-Y371-CBL [cytosol]
(R-MMU-182940)
phospho-p-Y700,Y731,Y774-CBL [cytosol]
(R-MMU-912656)
phospho-p-Y-CBL [cytosol]
(R-MMU-8875457)
CBL [cytosol]
(R-MMU-112199)
0.499
2
UniProt:P32883 Kras
17
phospho-p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-MMU-9674821)
S-Farn-Me KRAS4A [plasma membrane]
(R-MMU-9647811)
phospho-pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
(R-MMU-9653578)
S-Farn-Me KRAS4B [cytosol]
(R-MMU-9654510)
phospho-pS181-S-Farn-Me KRAS4B [plasma membrane]
(R-MMU-9653482)
Kras [plasma membrane]
(R-MMU-1250483)
S-Farn-Me PalmS KRAS4A [Golgi membrane]
(R-MMU-9647903)
S-Farn-Me KRAS [endoplasmic reticulum membrane]
(R-MMU-9647801)
S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649690)
S-Farn-KRAS [endoplasmic reticulum membrane]
(R-MMU-9647790)
S-Farn KRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649698)
S-Farn proKRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649693)
S-Farn-proKRAS [endoplasmic reticulum membrane]
(R-MMU-9647925)
proKRAS [cytosol]
(R-MMU-9647762)
pro-KRAS4A [cytosol]
(R-MMU-9649683)
S-Farn-Me-PalmS KRAS4A [plasma membrane]
(R-MMU-9647915)
S-Farn-Me KRAS4B [plasma membrane]
(R-MMU-9647815)
0.463
3
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