Reactome | Rps27 [cytosol]

Rps27 [cytosol]

Stable Identifier

R-MMU-72361

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPS27, Q6ZWU9

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - Mitotic Spindle Checkpoint (Mus musculus)
    - Amplification of signal from the kinetochores (Mus musculus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Mus musculus)
        
        MAD2 associates with the Mad1 kinetochore complex (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Mad1 binds kinetochore (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Release of activated MAD2 from kinetochores (Mus musculus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Mad1:kinetochore complex [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - M Phase (Mus musculus)
    - Mitotic Metaphase and Anaphase (Mus musculus)
      - Mitotic Anaphase (Mus musculus)
        
        Separation of Sister Chromatids (Mus musculus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Separation of sister chromatids (Mus musculus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
    - Mitotic Prometaphase (Mus musculus)
      - EML4 and NUDC in mitotic spindle formation (Mus musculus)
        
        EML4 recruits NUDC to mitotic spindle (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - Kinetochore capture of astral microtubules (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - Resolution of Sister Chromatid Cohesion (Mus musculus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Kinetochore assembly (Mus musculus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Mus musculus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Mus musculus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Mus musculus)
        
        Microtubule-bound kinetochore [cytosol] (Mus musculus)
        
        Kinetochore [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Translation (Mus musculus)
  - Eukaryotic Translation Initiation (Mus musculus)
    - Cap-dependent Translation Initiation (Mus musculus)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Mus musculus)
        
        Translation initiation complex formation (Mus musculus)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        48S complex [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - Formation of a pool of free 40S subunits (Mus musculus)
        
        Release of 40S and 60S subunits from the 80S ribosome (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        eIF3 and eIF1A bind to the 40S subunit (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        40S:eIF3:eIF1A [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - Formation of the ternary complex, and subsequently, the 43S complex (Mus musculus)
        
        Formation of the 43S pre-initiation complex (Mus musculus)
        
        40S:eIF3:eIF1A [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
        
        The 60S subunit joins the translation initiation complex (Mus musculus)
        
        40S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        eIF2:GTP is hydrolyzed, eIFs are released (Mus musculus)
        
        40S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        48S complex [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        eIF5B:GTP is hydrolyzed and released (Mus musculus)
        
        80S:Met-tRNAi:mRNA [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - Ribosomal scanning and start codon recognition (Mus musculus)
        
        Ribosomal scanning (Mus musculus)
        
        48S complex [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        Start codon recognition (Mus musculus)
        
        48S complex [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Mus musculus)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Mus musculus)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
        
        43S complex [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
  - Ribosome-associated quality control (Mus musculus)
    - PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (Mus musculus)
      - ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (Mus musculus)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide (Mus musculus)
        
        ABCE1:ADP:40S ribosomal subunit [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
    - ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Mus musculus)
      - RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide (Mus musculus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        K63polyUb-80S ribosome [cytosol] (Mus musculus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] (Mus musculus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        K63polyUb-80S ribosome [cytosol] (Mus musculus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Mus musculus)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        K63polyUb-80S ribosome [cytosol] (Mus musculus)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Mus musculus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Mus musculus)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
  - SRP-dependent cotranslational protein targeting to membrane (Mus musculus)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Mus musculus)
      - SRP:polypeptide+signal:ribosome [cytosol] (Mus musculus)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        RPS27,RPS27L [cytosol] (Mus musculus)
        
        Rps27 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6ZWU9 Rps27

Gene Names

Rps27

Chain

chain:1-84

Reference Genes

BioGPS Gene:100043813 Rps27

BioGPS Gene:57294 Rps27

CTD Gene:100043813 Rps27

KEGG:mmu:100043813 Rps27

KEGG:mmu:57294 Rps27

Monarch:100043813 Rps27

Monarch:57294 Rps27

NCBI Gene:100043813 Rps27

NCBI Gene:57294 Rps27

UCSC:Q6ZWU9 Rps27

Reference Transcript

Other Identifiers

100043813

10338232

10339822

10340193

10340245

10340618

10340957

10343282

10499748

10597490

1415716_a_at

1460699_at

17205971

17205973

17407240

17531954

4351465

4415436

4424154

4439803

4617768

4642858

4933016

5071851

5104696

5265068

5369166

5391661

5407598

5516907

5602409

57294

96300_f_at

96301_at

A_55_P2155438

A_55_P2158112

GE42405

GO:0000028

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0008270

GO:0022627

GO:0032040

GO:0042274

GO:0045202

GO:0046872

GO:0065003

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1990904

ILMN_2669015

aa036204_s_at

mMC021606

Participates

as a member of

RPS27,RPS27L [cytosol] (Mus musculus)

as a component of

Kinetochore [cytosol] (Mus musculus)

Other forms of this molecule

Rps27 [nucleoplasm]

Rps27 [cytosol]

Inferred From

RPS27 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_081291.1, NP_001177187.1

ENSEMBL

ENSMUST00000170122, ENSMUSP00000060523, ENSMUSG00000050621, ENSMUSP00000132102, ENSMUSG00000090733, ENSMUST00000053150

PRO

Q6ZWU9

MGI

1888676

PDB

7CPU, 7CPV

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