Reactome | Rps17 [cytosol]

Rps17 [cytosol]

Stable Identifier

R-MMU-72339

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPS17, P63276

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Mus musculus)
        
        40S ribosomal complex [cytosol] (Mus musculus)
        
        Rps17 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P63276 Rps17

Gene Names

Rps17

Chain

chain:1-135

Reference Genes

BioGPS Gene:20068 Rps17

KEGG:mmu:20068 Rps17

Monarch:20068 Rps17

NCBI Gene:20068 Rps17

UCSC:P63276 Rps17

Reference Transcript

RefSeq:NM_009092.3 Rps17

Other Identifiers

10374476

10565083

10604597

1437510_x_at

1438501_at

1438502_x_at

1438986_x_at

1455662_x_at

1459986_a_at

17492745

20068

4349435

4376714

4447321

4484405

4527165

4544160

4631172

4722602

4773212

4999145

5011338

5029600

5042276

5122750

5151342

5206118

5212370

5228092

5253721

5314334

5325277

5337403

5364795

5428449

5491511

5515791

5574433

5607621

99590_at

A_51_P482473

D25213_f_at

GE33596

GO:0002181

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0022626

GO:0022627

GO:0032040

GO:0042274

GO:0045202

GO:0098794

GO:1990904

ILMN_2675747

mMC020092

Participates

as a component of

Other forms of this molecule

Rps17 [nucleoplasm]

Rps17 [cytosol]

Inferred From

RPS17 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_033118.1

ENSEMBL

ENSMUSP00000079628, ENSMUST00000080813, ENSMUSG00000061787

PRO

P63276

GlyGen

P63276

MGI

1309526

PDB

7CPU, 7LS1, 7LS2, 7CPV

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