Reactome | Srsf5 [nucleoplasm]

Srsf5 [nucleoplasm]

Stable Identifier

R-MMU-72028

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

SRSF5, O35326

Locations in the PathwayBrowser

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Metabolism of RNA (Mus musculus)

- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - Formation of pre-mRNPs (Mus musculus)
    - Alternative Splicing Factors [nucleoplasm] (Mus musculus)
      - nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
      - Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
  - Transport of Mature Transcript to Cytoplasm (Mus musculus)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Mus musculus)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Mus musculus)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Mus musculus)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
  - mRNA 3'-end processing (Mus musculus)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Mus musculus)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Spliced mRNP [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
    - mRNA Polyadenylation (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Core CPA complex binds capped pre-mRNA (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - PP1 dephosphorylates RNA Pol II (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - RBBP6 activates CPSF complex (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
  - mRNA Splicing (Mus musculus)
    - mRNA Splicing - Major Pathway (Mus musculus)
      - Formation of the Spliceosomal B complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal B* complex (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal Bact complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C complex containing intron lariat (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C* complex (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal E complex (Mus musculus)
        
        Spliceosomal E complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal P complex and exon ligation (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        nonshuttling SRSFs [nucleoplasm] (Mus musculus)
        
        Srsf5 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:O35326

Gene Names

Srsf5

Reference Genes

BioGPS Gene:20384 Srsf5

ENSEMBL:ENSMUSG00000021134

KEGG:mmu:20384 Srsf5

Monarch:20384 Srsf5

NCBI Gene:20384 Srsf5

UCSC:O35326 Srsf5

Reference Transcript

Other Identifiers

10396926

10508490

1423130_a_at

17276893

20384

4305536

4315529

4338958

4384215

4422123

4424858

4451731

4513181

4584460

4603378

4606005

4710097

4768195

4851126

4853761

4875001

4919814

4924459

4939329

5033460

5128858

5132481

5142308

5146848

5224437

5232808

5253789

5420356

5449620

5494664

5548971

5601679

5611159

99628_at

A_52_P50090

A_55_P2157872

A_55_P2726980

GE42570

GO:0000381

GO:0001889

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005829

GO:0006397

GO:0008380

GO:0009611

GO:0016071

GO:0016607

GO:0032868

GO:0032869

GO:0033120

GO:0043422

GO:0048856

GO:0050733

GO:0097421

ILMN_1226145

ILMN_2772274

ILMN_3148662

Msa.9979.0_s_at

aa388848_s_at

mMC024026

Participates

as a member of

nonshuttling SRSFs [nucleoplasm] (Mus musculus)

as a component of

Inferred From

SRSF5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001334345.1, NP_001073163.1, NP_001073162.1, NP_033185.2

ENSEMBL

ENSMUST00000094693, ENSMUST00000110356, ENSMUSP00000105985, ENSMUSG00000021134, ENSMUSP00000105981, ENSMUSP00000131323, ENSMUST00000110352

PRO

O35326

GlyGen

O35326

MGI

98287

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