Reactome | Cstf2 [nucleoplasm]

Cstf2 [nucleoplasm]

Stable Identifier

R-MMU-72003

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

CSTF2, Q8BIQ5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA Polymerase II Transcription Termination (Mus musculus)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)
      - CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Mus musculus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)

Metabolism of RNA (Mus musculus)

- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - mRNA 3'-end processing (Mus musculus)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Mus musculus)
      - Spliced mRNP [nucleoplasm] (Mus musculus)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
    - mRNA Polyadenylation (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - Core CPA complex binds capped pre-mRNA (Mus musculus)
        
        Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - Formation of the CSTF complex (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - Formation of the core cleavage and polyadenylation complex (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - PP1 dephosphorylates RNA Pol II (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        CPA complex [nucleoplasm] (Mus musculus)
        
        Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        CPA complex [nucleoplasm] (Mus musculus)
        
        Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - RBBP6 activates CPSF complex (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        CPA complex [nucleoplasm] (Mus musculus)
        
        Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA complex [nucleoplasm] (Mus musculus)
        
        Ub-K63-Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        CPA complex [nucleoplasm] (Mus musculus)
        
        Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Core CPA complex [nucleoplasm] (Mus musculus)
        
        CSTF hexamer [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
- Processing of Capped Intronless Pre-mRNA (Mus musculus)
  - Processing of Intronless Pre-mRNAs (Mus musculus)
    - Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Mus musculus)
      - CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Mus musculus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
    - Cleavage and polyadenylation of Intronless Pre-mRNA (Mus musculus)
      - CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Mus musculus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Mus musculus)
      - CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Mus musculus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
    - Recruitment of CstF to the CPSF Bound Pre-mRNA (Mus musculus)
      - CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)
      - CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        CSTF heterotrimer [nucleoplasm] (Mus musculus)
        
        CSTF2,CSTF2T [nucleoplasm] (Mus musculus)
        
        Cstf2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BIQ5

Gene Names

Cstf2

Reference Genes

BioGPS Gene:108062 Cstf2

ENSEMBL:ENSMUSG00000031256

KEGG:mmu:108062 Cstf2

Monarch:108062 Cstf2

NCBI Gene:108062 Cstf2

UCSC:Q8BIQ5 Cstf2

Reference Transcript

Other Identifiers

104399_at

105599_at

10601673

108062

1419644_at

1419645_at

1455523_at

17537607

17537630

4314132

4325597

4559851

4570541

4633759

4634477

4656013

4764676

4780519

4802027

4858319

4890423

4917886

5064446

5071022

5100774

5126666

5128645

5172276

5172532

5265584

5294532

5332103

5357355

5365209

5365657

5373696

5429187

5481343

5536025

5598914

AA261527_at

A_51_P119460

A_52_P161674

A_52_P415360

A_55_P2080703

A_55_P2080708

A_66_P116154

GE42254

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005847

GO:0006397

GO:0016071

GO:0016604

GO:0031124

GO:0071920

GO:1990090

ILMN_1238915

ILMN_2698589

Msa.22514.0_s_at

Msa.30939.0_s_at

mMC012785

Participates

as a member of

CSTF2,CSTF2T [nucleoplasm] (Mus musculus)

Inferred From

CSTF2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_573459.1, NP_001277328.1

ENSEMBL

ENSMUST00000113286, ENSMUSP00000108911, ENSMUSP00000033609, ENSMUST00000033609, ENSMUSG00000031256

PRO

Q8BIQ5

MGI

1343054

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