Reactome | Hnrnpl [nucleoplasm]

Hnrnpl [nucleoplasm]

Stable Identifier

R-MMU-71947

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

HNRNPL, Q8R081

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - Formation of pre-mRNPs (Mus musculus)
    - Alternative Splicing Factors [nucleoplasm] (Mus musculus)
      - shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
      - Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
  - mRNA 3'-end processing (Mus musculus)
    - mRNA Polyadenylation (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Core CPA complex binds capped pre-mRNA (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - PP1 dephosphorylates RNA Pol II (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - RBBP6 activates CPSF complex (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
  - mRNA Splicing (Mus musculus)
    - mRNA Splicing - Major Pathway (Mus musculus)
      - Formation of the Spliceosomal B complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal B* complex (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal Bact complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C complex containing intron lariat (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C* complex (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal E complex (Mus musculus)
        
        Spliceosomal E complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal P complex and exon ligation (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        shuttling HNRNPs [nucleoplasm] (Mus musculus)
        
        Hnrnpl [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8R081

Gene Names

Hnrnpl

Reference Genes

BioGPS Gene:15388 Hnrnpl

ENSEMBL:ENSMUSG00000015165

KEGG:mmu:15388 Hnrnpl

Monarch:15388 Hnrnpl

NCBI Gene:15388 Hnrnpl

UCSC:Q8R081 Hnrnpl

Reference Transcript

RefSeq:NM_177301.5 Hnrnpl

Other Identifiers

10551600

1424101_at

1445594_at

15388

17475956

4310976

4418076

4469574

4505776

4546369

4575046

4581368

4581579

4645217

4646817

4662183

4693124

4715068

4740263

4740598

4808190

4814438

4817789

4843525

4900106

5074751

5183736

5188241

5279116

5308940

5429750

5436746

5462881

5491408

5556218

95232_at

A_55_P2339650

A_55_P2610837

A_55_P2715540

C79783_rc_f_at

GE33225

GO:0000381

GO:0000785

GO:0000976

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0006397

GO:0016071

GO:0035770

GO:0043226

GO:0043484

GO:0045120

GO:0045202

GO:0045892

GO:0097157

GO:1990904

ILMN_1231516

ILMN_1252067

ILMN_2580691

ILMN_2627690

mMC017857

Participates

as a member of

shuttling HNRNPs [nucleoplasm] (Mus musculus)

Inferred From

HNRNPL [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_796275.3

ENSEMBL

ENSMUST00000038572, ENSMUSP00000049407, ENSMUSG00000015165, ENSMUSP00000133728, ENSMUST00000174548

PRO

Q8R081

GlyGen

Q8R081

MGI

104816

PDB

3TYT, 3S01

Cite Us!