Reactome | Pcbp1 [nucleoplasm]

Pcbp1 [nucleoplasm]

Stable Identifier

R-MMU-71919

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

PCBP1, P60335

Locations in the PathwayBrowser

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Metabolism of RNA (Mus musculus)

- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - Formation of pre-mRNPs (Mus musculus)
    - Alternative Splicing Factors [nucleoplasm] (Mus musculus)
      - Pcbp1 [nucleoplasm] (Mus musculus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
      - Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
  - mRNA 3'-end processing (Mus musculus)
    - mRNA Polyadenylation (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Core CPA complex binds capped pre-mRNA (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - PP1 dephosphorylates RNA Pol II (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - RBBP6 activates CPSF complex (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
  - mRNA Splicing (Mus musculus)
    - mRNA Splicing - Major Pathway (Mus musculus)
      - Formation of the Spliceosomal B complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal B* complex (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal Bact complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C complex containing intron lariat (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C* complex (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal E complex (Mus musculus)
        
        Spliceosomal E complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal P complex and exon ligation (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        Alternative Splicing Factors [nucleoplasm] (Mus musculus)
        
        Pcbp1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P60335

Gene Names

Pcbp1

Reference Genes

BioGPS Gene:23983 Pcbp1

ENSEMBL:ENSMUSG00000051695

KEGG:mmu:23983 Pcbp1

Monarch:23983 Pcbp1

NCBI Gene:23983 Pcbp1

UCSC:P60335 Pcbp1

Reference Transcript

RefSeq:NM_011865.4 Pcbp1

Other Identifiers

10545917

1448642_at

17468505

23983

4408819

4582967

4622809

4634139

4753369

4757664

4854013

5039219

5087193

5396286

94552_at

A_51_P248544

A_52_P241129

A_55_P1980326

GE42694

GO:0000981

GO:0003676

GO:0003677

GO:0003697

GO:0003723

GO:0003729

GO:0003730

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006397

GO:0008494

GO:0014069

GO:0016071

GO:0016607

GO:0034986

GO:0036464

GO:0039694

GO:0043226

GO:0045727

GO:0045944

GO:0051604

GO:0098847

GO:0140104

GO:1990904

ILMN_2702197

mMC014191

Participates

as a member of

Alternative Splicing Factors [nucleoplasm] (Mus musculus)

Inferred From

PCBP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_035995.1

ENSEMBL

ENSMUST00000053015, ENSMUSG00000051695, ENSMUSP00000054863

PRO

P60335

GlyGen

P60335

MGI

1345635

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