Reactome | MCM3 [nucleoplasm]

MCM3 [nucleoplasm]

Stable Identifier

R-MMU-68546

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

P25206

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - Activation of ATR in response to replication stress (Mus musculus)
      - Activation of claspin (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - Loading of claspin onto DNA during replication origin firing (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Activation of the pre-replicative complex (Mus musculus)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        Cdt1 is displaced from the pre-replicative complex (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        DNA polymerase alpha:primase binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        DNA polymerase epsilon binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
        
        MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        Mcm2-7 is phosphorylated by DDK (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        p-MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Synthesis of DNA (Mus musculus)
      - Switching of origins to a post-replicative state (Mus musculus)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        Orc1 removal from chromatin (Mus musculus)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)

DNA Replication (Mus musculus)

- DNA Replication Pre-Initiation (Mus musculus)
  - Activation of the pre-replicative complex (Mus musculus)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
    - Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
    - Cdt1 is displaced from the pre-replicative complex (Mus musculus)
      - MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
    - DNA polymerase alpha:primase binds at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
    - DNA polymerase epsilon binds at the origin (Mus musculus)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Mus musculus)
      - MCM10:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
    - Mcm2-7 is phosphorylated by DDK (Mus musculus)
      - MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - p-MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
  - Assembly of the pre-replicative complex (Mus musculus)
    - Formation of MCM2-7 complex (Mus musculus)
      - MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
    - MCM3 binds MCM5 (Mus musculus)
      - MCM3 [nucleoplasm] (Mus musculus)
      - MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
- Synthesis of DNA (Mus musculus)
  - Switching of origins to a post-replicative state (Mus musculus)
    - Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)
      - MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
      - MCM3 [nucleoplasm] (Mus musculus)
    - Orc1 removal from chromatin (Mus musculus)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Mus musculus)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)
        
        pre-replicative complex [nucleoplasm] (Mus musculus)
        
        MCM2-7 [nucleoplasm] (Mus musculus)
        
        MCM3:MCM5 [nucleoplasm] (Mus musculus)
        
        MCM3 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P25206

Reference Genes

BioGPS Gene:17215

ENSEMBL:ENSMUSG00000041859

KEGG:mmu:17215

Monarch:17215

NCBI Gene:17215

UCSC:P25206

Reference Transcript

RefSeq:NM_008563.3

Other Identifiers

100062_at

10353420

1420028_s_at

1426652_at

1426653_at

1449705_x_at

160496_s_at

17215

17221633

4325482

4459894

4592810

4609750

4635231

4763040

4792805

4863540

4883247

4989217

5101446

5131351

5141004

5258366

5325697

5351685

5401426

5431468

5432479

5449619

5491296

5561983

5574586

A_52_P364776

A_55_P1953087

A_55_P2499523

GE32916

GO:0000166

GO:0000727

GO:0003677

GO:0003697

GO:0003824

GO:0004386

GO:0005524

GO:0005634

GO:0005694

GO:0005737

GO:0006260

GO:0006270

GO:0006271

GO:0006279

GO:0006281

GO:0006310

GO:0016787

GO:0016887

GO:0017116

GO:0022414

GO:0042555

GO:0048471

GO:0071162

GO:0140097

GO:0140657

GO:1902975

ILMN_2633377

ILMN_2851040

Msa.42771.0_s_at

X62154_s_at

mMC018741

Participates

as an output of

Mcm4,6,7 trimer forms and associates with the replication fork (Mus musculus)

as an input of

MCM3 binds MCM5 (Mus musculus)

as a component of

MCM3:MCM5 [nucleoplasm] (Mus musculus)

Inferred From

MCM3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_032589.1

ENSEMBL

ENSMUST00000053266, ENSMUSG00000041859, ENSMUSP00000059192

IntEnz

3.6.4.12

PRO

P25206

GlyGen

P25206

MGI

101845

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