Reactome | DNA2 [nucleoplasm]

DNA2 [nucleoplasm]

Stable Identifier

R-MMU-68465

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q6ZQJ5

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - G2/M DNA damage checkpoint (Mus musculus)
      - ATR phosphorylates TP53 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - S Phase (Mus musculus)
    - Synthesis of DNA (Mus musculus)
      - DNA strand elongation (Mus musculus)
        
        Lagging Strand Synthesis (Mus musculus)
        
        Processive synthesis on the lagging strand (Mus musculus)
        
        Removal of the Flap Intermediate (Mus musculus)
        
        Recruitment of Dna2 endonuclease (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Removal of RNA primer and dissociation of RPA and Dna2 (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
- Chromosome Maintenance (Mus musculus)
  - Telomere Maintenance (Mus musculus)
    - Extension of Telomeres (Mus musculus)
      - Telomere C-strand (Lagging Strand) Synthesis (Mus musculus)
        
        Processive synthesis on the C-strand of the telomere (Mus musculus)
        
        Removal of the Flap Intermediate from the C-strand (Mus musculus)
        
        Recruitment of DNA2 endonuclease to the C strand (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)

DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - Homology Directed Repair (Mus musculus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
      - HDR through Homologous Recombination (HRR) (Mus musculus)
        
        D-loop extension by DNA polymerases (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Homologous DNA Pairing and Strand Exchange (Mus musculus)
        
        CX3 complex binds D-loop structures (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Mus musculus)
        
        BCDX2 complex stabilizes RAD51 filament (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Resolution of D-Loop Structures (Mus musculus)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Mus musculus)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        FIGNL1 binds RAD51 (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        MUS81:EME1,EME2 cleaves D-loop (Mus musculus)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
      - HDR through Single Strand Annealing (SSA) (Mus musculus)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Completion of SSA (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA (Mus musculus)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        LIG1 binds SSA sites (Mus musculus)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        LIG1:ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ERCC1:ERCC4:RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
      - Processing of DNA double-strand break ends (Mus musculus)
        
        ATR activation at DNA DSBs (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        ATR phosphorylates RPA2 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Activation of CHEK1 at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        CHEK1 is recruited to resected DNA DSBs (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Phosphorylation (Mus musculus)
        
        ATR phosphorylates TP53 (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)
        
        DNA2:WRN [nucleoplasm] (Mus musculus)
        
        DNA2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q6ZQJ5

Reference Genes

BioGPS Gene:327762

ENSEMBL:ENSMUSG00000036875

KEGG:mmu:327762

Monarch:327762

NCBI Gene:327762

UCSC:Q6ZQJ5

Reference Transcript

Other Identifiers

103444_at

10363575

114587_at

1438817_at

1452210_at

1457909_at

17233811

327762

4323303

4345665

4354596

4367206

4379784

4380351

4493121

4532892

4575151

4581538

4629266

4653568

4691903

4694379

4703382

4880361

4931292

5056516

5100244

5102737

5136419

5136957

5231212

5252545

5296247

5327044

5329612

5425089

5555620

5585726

5596596

5606870

A_52_P437201

A_52_P513123

A_55_P2742346

A_65_P07712

GE1510879

GO:0000076

GO:0000166

GO:0000723

GO:0000729

GO:0000781

GO:0003677

GO:0003723

GO:0003824

GO:0004386

GO:0004518

GO:0004519

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005760

GO:0006260

GO:0006264

GO:0006281

GO:0006284

GO:0006974

GO:0016787

GO:0016887

GO:0017108

GO:0017116

GO:0032200

GO:0032201

GO:0033567

GO:0033892

GO:0042645

GO:0043137

GO:0043139

GO:0043504

GO:0045740

GO:0046872

GO:0051536

GO:0051539

GO:0071932

GO:0140097

GO:0140657

GO:1902990

ILMN_2729224

aa407737_s_at

mMC003602

Participates

as an output of

as an input of

as a component of

Inferred From

DNA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_036011717.1, NP_796346.2

ENSEMBL

ENSMUST00000131422, ENSMUST00000092462, ENSMUSP00000090119, ENSMUSG00000036875, ENSMUSP00000115750

PRO

Q6ZQJ5

GlyGen

Q6ZQJ5

MGI

2443732

PDB

5EAX, 5EAW, 5EAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O35144 Terf2	3	Telomeric repeat-binding factor 2 [nucleoplasm] (R-MMU-912401) phospho-Terf2 [nucleoplasm] (R-MMU-9686530) Terf2 [nucleoplasm] (R-MMU-174895)	0.576	4
UniProt:P70371 Terf1	2	Telomeric repeat-binding factor 1 [nucleoplasm] (R-MMU-912412) Terf1 [nucleoplasm] (R-MMU-164618)	0.576	4

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