Reactome | DBF4 [nucleoplasm]

DBF4 [nucleoplasm]

Stable Identifier

R-MMU-68387

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q9QZ41

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G2/M Checkpoints (Mus musculus)
    - Activation of ATR in response to replication stress (Mus musculus)
      - Activation of claspin (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
      - Loading of claspin onto DNA during replication origin firing (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Activation of the pre-replicative complex (Mus musculus)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        DNA polymerase alpha:primase binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        DNA polymerase epsilon binds at the origin (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)
        
        Mcm2-7 is phosphorylated by DDK (Mus musculus)
        
        DDK [nucleoplasm] (Mus musculus)
        
        DBF4 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QZ41

Reference Genes

BioGPS Gene:27214

ENSEMBL:ENSMUSG00000002297

KEGG:mmu:27214

Monarch:27214

NCBI Gene:27214

UCSC:Q9QZ41

Reference Transcript

Other Identifiers

10528077

1418334_at

1430545_at

160687_r_at

17445507

27214

4404480

4478779

4604101

4624340

4665481

4683527

4851949

4881605

4903311

4972506

5095402

5115047

5116394

5131001

5134975

5170184

5295977

5307564

5311386

5320397

5397845

5422542

5561854

5570750

5573554

A_52_P397418

A_52_P404570

A_55_P2717004

GE1560630

GO:0003676

GO:0003824

GO:0004674

GO:0005634

GO:0005654

GO:0006260

GO:0007089

GO:0008270

GO:0010571

GO:0016604

GO:0016740

GO:0031431

GO:0043539

GO:0046872

GO:0098772

GO:0140096

GO:1901987

ILMN_1212696

ILMN_1213084

ILMN_1254470

ILMN_2556182

ILMN_2579122

ILMN_2952661

aa690055_at

aa692716_at

aa692716_g_at

mMC015340

Participates

as a component of

DDK [nucleoplasm] (Mus musculus)

Inferred From

DBF4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_038754.1, NP_001177646.1

ENSEMBL

ENSMUST00000171808, ENSMUSG00000002297, ENSMUSP00000132906, ENSMUST00000002368, ENSMUSP00000002368

PRO

Q9QZ41

MGI

1351328

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