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CDK2 [nucleoplasm]
Stable Identifier
R-MMU-68365
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
P97377
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G1/S DNA Damage Checkpoints (Mus musculus)
p53-Dependent G1/S DNA damage checkpoint (Mus musculus)
p53-Dependent G1 DNA Damage Response (Mus musculus)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
G2/M Checkpoints (Mus musculus)
Activation of ATR in response to replication stress (Mus musculus)
Activation of claspin (Mus musculus)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Loading of claspin onto DNA during replication origin firing (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G1 phase and G1/S transition (Mus musculus)
G0 and Early G1 (Mus musculus)
p107 (RBL1) binds CyclinE/A:CDK2 (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
RBL1:Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
p130 (RBL2) binds Cyclin E/A:CDK2 (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
RBL2:Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
G1/S Transition (Mus musculus)
Activation of the pre-replicative complex (Mus musculus)
CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
DNA polymerase alpha:primase binds at the origin (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
DNA polymerase epsilon binds at the origin (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin E associated events during G1/S transition (Mus musculus)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Phosphorylation of Cyclin E:CDK2 complexes by WEE1 (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Translocation of Cyclin E:Cdk2 complex to the nucleus (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
S Phase (Mus musculus)
Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin A:Cdk2:phospho-p27/p21 complex [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Translocation of Cyclin A:Cdk2 complexes to the nucleus (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular Senescence (Mus musculus)
DNA Damage/Telomere Stress Induced Senescence (Mus musculus)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Senescence-Associated Secretory Phenotype (SASP) (Mus musculus)
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
DNA Replication (Mus musculus)
DNA Replication Pre-Initiation (Mus musculus)
Activation of the pre-replicative complex (Mus musculus)
CDK and DDK associate with the Mcm10:pre-replicative complex (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cdc45 associates with the pre-replicative complex at the origin (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
DNA polymerase alpha:primase binds at the origin (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
DNA polymerase epsilon binds at the origin (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Mus musculus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Developmental Biology (Mus musculus)
Transcriptional regulation of granulopoiesis (Mus musculus)
CEBPA binds CDK2 (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
CEBPA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
TP53 Regulates Transcription of Cell Cycle Genes (Mus musculus)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Mus musculus)
Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Inactivation of Cyclin E:Cdk2 complexes by p27/p21 (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CDK2 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P97377 Cdk2
Gene Names
Cdk2, Cdkn2
Chain
chain:1-346
Reference Genes
BioGPS Gene:12566 Cdk2
KEGG:mmu:12566 Cdk2
Monarch:12566 Cdk2
NCBI Gene:12566 Cdk2
UCSC:P97377 Cdk2
Reference Transcript
RefSeq:NM_016756.5 Cdk2
RefSeq:NM_183417.4 Cdk2
Other Identifiers
10373530
12566
1416873_a_at
17246299
4365550
4402655
4529624
4539894
4717890
4748689
4839059
4911777
4983803
5006192
5017279
5033439
5195464
5266697
5290062
5318887
5418992
5441562
5497236
5502298
94412_at
A_51_P266521
A_52_P651298
A_55_P2011852
GE37021
GO:0000082
GO:0000122
GO:0000166
GO:0000287
GO:0000307
GO:0000723
GO:0000781
GO:0000793
GO:0000805
GO:0000806
GO:0001673
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005768
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006468
GO:0006813
GO:0006974
GO:0007099
GO:0007165
GO:0007265
GO:0008284
GO:0010389
GO:0010468
GO:0015030
GO:0016301
GO:0016740
GO:0018105
GO:0019904
GO:0022414
GO:0030332
GO:0031453
GO:0031848
GO:0032200
GO:0032298
GO:0035173
GO:0043247
GO:0043687
GO:0045893
GO:0046872
GO:0051301
GO:0051321
GO:0051726
GO:0097123
GO:0097124
GO:0097134
GO:0097135
GO:0097472
GO:0106310
GO:0140096
ILMN_1218470
ILMN_1233064
ILMN_1250942
ILMN_2717613
ILMN_2770759
U63337_s_at
mMC009612
Participates
as an input of
CEBPA binds CDK2 (Mus musculus)
as a component of
CEBPA:CDK2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2 [nucleoplasm] (Mus musculus)
CCNE:CDK2 [nucleoplasm] (Mus musculus)
CCNA:CDK2 [nucleoplasm] (Mus musculus)
CDK [nucleoplasm] (Mus musculus)
Other forms of this molecule
Cdk2 [nucleoplasm]
phospho-p-Y15-CDK2 [nucleoplasm]
phospho-p-CDK2 [nucleoplasm]
CDK2 [cytosol]
phospho-p-T160-CDK2 [nucleoplasm]
Inferred From
CDK2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_058036.1
,
NP_904326.1
ENSEMBL
ENSMUSP00000026415
,
ENSMUSG00000025358
,
ENSMUST00000026415
,
ENSMUST00000026416
,
ENSMUSP00000026416
PRO
P97377
MGI
104772
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q61457
2
Ccne1 [nucleoplasm]
(R-MMU-68363)
Ccne1 [cytosol]
(R-MMU-157443)
0.589
3
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