Reactome | Ppl [cytosol]

Ppl [cytosol]

Stable Identifier

R-MMU-6810850

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

PPL, Q9R269

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Keratinization (Mus musculus)
  - Formation of the cornified envelope (Mus musculus)
    - CASP14 cleaves filaggrin (Mus musculus)
      - Late cornified envelope [plasma membrane] (Mus musculus)
        
        Cornified envelope:CDSN [plasma membrane] (Mus musculus)
        
        Cornified envelope [plasma membrane] (Mus musculus)
        
        Early cornified envelope [plasma membrane] (Mus musculus)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
      - Mature cornified envelope [plasma membrane] (Mus musculus)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Mus musculus)
        
        No FGN-Cornified envelope [plasma membrane] (Mus musculus)
        
        No FGN-late cornified envelope [plasma membrane] (Mus musculus)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
    - CDSN binds the cornified envelope (Mus musculus)
      - Cornified envelope [plasma membrane] (Mus musculus)
        
        Early cornified envelope [plasma membrane] (Mus musculus)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
      - Cornified envelope:CDSN [plasma membrane] (Mus musculus)
        
        Cornified envelope [plasma membrane] (Mus musculus)
        
        Early cornified envelope [plasma membrane] (Mus musculus)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
    - EVL:PPL heterodimer binds the inner surface of the plasma membrane (Mus musculus)
      - EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
      - EVPL:PPL:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
    - Envoplakin binds periplakin (Mus musculus)
      - EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
      - Ppl [cytosol] (Mus musculus)
    - Kazrin binds periplakin (Mus musculus)
      - KAZN:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
      - Ppl [cytosol] (Mus musculus)
    - Lamellar bodies bind the early cornified envelope (Mus musculus)
      - Cornified envelope [plasma membrane] (Mus musculus)
        
        Early cornified envelope [plasma membrane] (Mus musculus)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
      - Early cornified envelope [plasma membrane] (Mus musculus)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)
    - Plasma membrane resorption (Mus musculus)
      - Mature cornified envelope [plasma membrane] (Mus musculus)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Mus musculus)
        
        No FGN-Cornified envelope [plasma membrane] (Mus musculus)
        
        No FGN-late cornified envelope [plasma membrane] (Mus musculus)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL:Cell surface [plasma membrane] (Mus musculus)
        
        EVPL:PPL [cytosol] (Mus musculus)
        
        Ppl [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9R269

Gene Names

Ppl

Reference Genes

BioGPS Gene:19041 Ppl

ENSEMBL:ENSMUSG00000039457

KEGG Gene (Mus musculus):19041 Ppl

Monarch:19041 Ppl

NCBI Gene:19041 Ppl

Reference Transcript

RefSeq:NM_008909.2 Ppl

Participates

as an input of

as a component of

Other forms of this molecule

Ppl [cornified envelope]

Inferred From

PPL [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_032935.2

PRO

Q9R269

MGI

1194898

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20152	9	Vim [cytosol] (R-MMU-350264) Vim [cytosol] (R-MMU-350294) Vim [cytosol] (R-MMU-350316) Vim [cytosol] (R-MMU-350317) Vim [cytosol] (R-MMU-350314) Vim [cytosol] (R-MMU-350323) Vim [cytosol] (R-MMU-201600) Vim [microtubule organizing center] (R-MMU-9657898) Vim [cytosol] (R-MMU-9646687)	0.508	2
UniProt:Q01314 AKT1			0.508	2