Mbtps1,2 cleaves Creb3l3 to Creb3l3(1-?) and Creb3l3(?-461)

Stable Identifier
R-MMU-6784684
Type
Reaction [omitted]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Mbtps1,2 cleaves Creb3l3 to Creb3l3(1-?) and Creb3l3(?-461)
Creb3l3 is a transcription factor that is highly and selectively expressed in liver and small intestine. This protein is produced as an ER-localized type II transmembrane glycoprotein that is converted into the mature nuclear form (the N-terminal portion) by sequence specific proteases, Site-1 protease (S1P) and Site-2 protease (S2P). Creb3l3 is a downstream target gene of hepatocyte nuclear factor 4a (HNF-4a), which plays a critical role in hepatocyte differentiation and liver function. Ablation of HNF-4a abolished CREB-H mRNA expression in the liver, but not in the small intestine, suggesting an essential role of HNF-4a in hepatic CREB-H expression.
Literature References
PubMed ID Title Journal Year
18704925 Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H

Kaufman, RJ, Zhang, K, Li, J, Duncan, SA, Si-Tayeb, K, Chhinder, S, Garrison, W, Luebke-Wheeler, J, Battle, M

Hepatology 2008
22262056 The role of CREB-H transcription factor in triglyceride metabolism

Lee, AH

Curr. Opin. Lipidol. 2012
16469704 Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Kaufman, RJ, Zhang, K, Back, SH, Shen, X, Sakaki, K, Wu, J, Rutkowski, DT, Saunders, T

Cell 2006
Participants
Catalyst Activity

metalloendopeptidase activity of Mbtps1,2 [endoplasmic reticulum membrane]

Orthologous Events
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