Mbtps1,2 cleaves Creb3l3 to Creb3l3(1-?) and Creb3l3(?-461)

Stable Identifier
R-MMU-6784684
Type
Reaction [omitted]
Species
Mus musculus
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Mbtps1,2 cleaves Creb3l3 to Creb3l3(1-?) and Creb3l3(?-461)
Creb3l3 is a transcription factor that is highly and selectively expressed in liver and small intestine. This protein is produced as an ER-localized type II transmembrane glycoprotein that is converted into the mature nuclear form (the N-terminal portion) by sequence specific proteases, Site-1 protease (S1P) and Site-2 protease (S2P). Creb3l3 is a downstream target gene of hepatocyte nuclear factor 4a (HNF-4a), which plays a critical role in hepatocyte differentiation and liver function. Ablation of HNF-4a abolished CREB-H mRNA expression in the liver, but not in the small intestine, suggesting an essential role of HNF-4a in hepatic CREB-H expression.
Literature References
PubMed ID Title Journal Year
18704925 Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H

Luebke-Wheeler, J, Zhang, K, Battle, M, Si-Tayeb, K, Garrison, W, Chhinder, S, Li, J, Kaufman, RJ, Duncan, SA

Hepatology 2008
22262056 The role of CREB-H transcription factor in triglyceride metabolism

Lee, AH

Curr. Opin. Lipidol. 2012
16469704 Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

Zhang, K, Shen, X, Wu, J, Sakaki, K, Saunders, T, Rutkowski, DT, Back, SH, Kaufman, RJ

Cell 2006
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of Mbtps1,2 [endoplasmic reticulum membrane]

Physical Entity
Mbtps1,2 [endoplasmic reticulum membrane] (Mus musculus)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461) (Homo sapiens)
Authored
Sanchis, A  (2015-05-12)
Reviewed
D'Eustachio, P  (2016-04-20)
Created
Sanchis, A  (2015-06-22)
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