Reactome | Creb3l3 (1-?) translocates from cytosol to nucleoplasm

Creb3l3 (1-?) translocates from cytosol to nucleoplasm

Stable Identifier

R-MMU-6784652

Type

Reaction [omitted]

Species

Mus musculus

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

General

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Creb3l3 (1-?) translocates from cytosol to nucleoplasm

The N-terminal fragment of Creb3l3 is released to the cytosol and translocated to the nucleus (Chan et al. 2010, Chin et al. 2005) to induce the transcriptional activation of different genes such as Apoa4, Apoa5, and Apoc2 apolipoproteins which exhibit stimulatory effects on lipoprotein lipase (LPL). Consistent with the essential role of LPL in TG clearance, Creb3l3 deficient mice showed hypertriglyceridemia, associated with defective production of these apolipoproteins and decreased LPL activity.

Literature References

PubMed ID	Title	Journal	Year
15800215	The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma Wong, CM, Jin, DY, Chan, CP, Chin, KT, Qiang, BQ, Ng, IO, Zhou, HJ, Yuan, JG, Lee, JM	Nucleic Acids Res.	2005
20356926	N-linked glycosylation is required for optimal proteolytic activation of membrane-bound transcription factor CREB-H Ng, IO, Mak, TY, Jin, DY, Chin, KT, Chan, CP	J. Cell. Sci.	2010