Reactome | POLR2B [nucleoplasm]

POLR2B [nucleoplasm]

Stable Identifier

R-MMU-63504

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q8CFI7

Locations in the PathwayBrowser

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DNA Repair (Mus musculus)

- Nucleotide Excision Repair (Mus musculus)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Mus musculus)
    - Dual incision in TC-NER (Mus musculus)
      - 3' incision by ERCC5 (XPG) in TC-NER (Mus musculus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Mus musculus)
        
        TC-NER incision complex [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Mus musculus)
        
        TC-NER incision complex [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Mus musculus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
        
        TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - ERCC5 and RPA bind TC-NER site (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Formation of TC-NER Pre-Incision Complex (Mus musculus)
      - Active RNA Pol II complex transcribes lesion-containing DNA template (Mus musculus)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Assembly of the pre-incision complex in TC-NER (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - ERCC6 binds stalled RNA Pol II (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - ERCC8 (CSA) binds stalled RNA Pol II (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA Pol II initiates transcription from damaged DNA template (Mus musculus)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - UVSSA:USP7 deubiquitinates ERCC6 (Mus musculus)
        
        TC-NER pre-incision complex [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Mus musculus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Mus musculus)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Mus musculus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Mus musculus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Mus musculus)
        
        Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - TP53 Regulates Transcription of DNA Repair Genes (Mus musculus)
        
        CCNK:CDK12 binds RNA Pol II at DNA repair genes (Mus musculus)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Mus musculus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Mus musculus)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Mus musculus)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Mus musculus)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Mus musculus)
        
        p-3S-RNA Pol II:TFIIF [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Mus musculus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Mus musculus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - RNA Pol II CTD phosphorylation and interaction with CE (Mus musculus)
    - Activation of GT (Mus musculus)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Mus musculus)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Phosphorylation (Ser5) of RNA pol II CTD (Mus musculus)
      - Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - RNA Polymerase II CTD (phosphorylated) binds to CE (Mus musculus)
      - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - RNA Polymerase II Pre-transcription Events (Mus musculus)
    - 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Mus musculus)
      - Paused processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Mus musculus)
      - Processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Abortive Initiation After Second Transition (Mus musculus)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Abortive Initiation Before Second Transition (Mus musculus)
      - Pol II Promoter Escape Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Abortive initiation after formation of the first phosphodiester bond (Mus musculus)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - pol II transcription complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Abortive termination of early transcription elongation by DSIF:NELF (Mus musculus)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Abortive termination of elongation after arrest (Mus musculus)
      - Aborted elongation complex after arrest [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Elongating transcript encounters a lesion in the template (Mus musculus)
      - Processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Fall Back to Closed Pre-initiation Complex (Mus musculus)
      - pol II closed pre-initiation complex [nucleoplasm] (Mus musculus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - pol II open pre-initiation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Resumption of elongation after recovery from pausing (Mus musculus)
      - Paused processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - TFIIS-mediated recovery of elongation from arrest (Mus musculus)
      - Processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - RNA Polymerase II Transcription Elongation (Mus musculus)
    - Addition of nucleotides leads to transcript elongation (Mus musculus)
      - Elongation complex [nucleoplasm] (Mus musculus)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Formation of RNA Pol II elongation complex (Mus musculus)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Mus musculus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Recruitment of elongation factors to form elongation complex (Mus musculus)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Elongation complex [nucleoplasm] (Mus musculus)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Formation of the Early Elongation Complex (Mus musculus)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of DSIF:NELF:early elongation complex (Mus musculus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Mus musculus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Pol II elongation complex moves on the template as transcript elongates (Mus musculus)
      - Elongation complex prior to separation [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Processive elongation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Separation of elongating transcript from template (Mus musculus)
      - Elongation complex prior to separation [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Elongation complex with separated and uncleaved transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - RNA Polymerase II Transcription Initiation And Promoter Clearance (Mus musculus)
    - RNA Polymerase II Promoter Escape (Mus musculus)
      - Addition of Nucleotides 5 through 9 on the growing Transcript (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Addition of nucleotides between position +11 and +30 (Mus musculus)
        
        Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Addition of the third nucleotide on the nascent transcript (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Unwinding DNA for the nascent transcript (Mus musculus)
        
        pol II transcription complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Unwinding of DNA for the Nascent Transcript: Second Transition (Mus musculus)
        
        pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - RNA Polymerase II Promoter Opening: First Transition (Mus musculus)
      - pol II closed pre-initiation complex [nucleoplasm] (Mus musculus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - pol II open pre-initiation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - RNA Polymerase II Transcription Initiation (Mus musculus)
      - NTP Binds Active Site of RNA Polymerase II (Mus musculus)
        
        Pol II initiation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II open pre-initiation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Newly Formed Phosphodiester Bond Stabilized and PPi Released (Mus musculus)
        
        Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        pol II transcription complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Mus musculus)
        
        Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Pol II initiation complex [nucleoplasm] (Mus musculus)
        
        RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (Mus musculus)
    - Binding of TFIIE to the growing preinitiation complex (Mus musculus)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] (Mus musculus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Formation of the closed pre-initiation complex (Mus musculus)
      - pol II closed pre-initiation complex [nucleoplasm] (Mus musculus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex [nucleoplasm] (Mus musculus)
        
        pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex (Mus musculus)
      - RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)
      - RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)

Metabolism of RNA (Mus musculus)

- Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
  - Formation of pre-mRNPs (Mus musculus)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
      - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - Internal Methylation of mRNA (Mus musculus)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Mus musculus)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - mRNA 3'-end processing (Mus musculus)
    - mRNA Polyadenylation (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Mus musculus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Core CPA complex binds capped pre-mRNA (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Mus musculus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - PP1 dephosphorylates RNA Pol II (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (RNA Pol II dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - RBBP6 activates CPSF complex (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (RNA Pol II dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex (RNA Pol II dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Mus musculus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Mus musculus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - mRNA Splicing (Mus musculus)
    - mRNA Splicing - Major Pathway (Mus musculus)
      - Formation of the Spliceosomal B complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal B* complex (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal Bact complex (Mus musculus)
        
        Spliceosomal B complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Spliceosomal Bact complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C complex containing intron lariat (Mus musculus)
        
        Spliceosomal B* complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal C* complex (Mus musculus)
        
        Spliceosomal C complex [nucleoplasm] (Mus musculus)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal E complex (Mus musculus)
        
        Spliceosomal E complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of the Spliceosomal P complex and exon ligation (Mus musculus)
        
        Spliceosomal C* complex [nucleoplasm] (Mus musculus)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Mus musculus)
        
        Spliceosomal P complex [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - mRNA Splicing - Minor Pathway (Mus musculus)
      - ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Mus musculus)
        
        ATAC C Complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        post exon ligation complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Mus musculus)
        
        ATAC C Complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of AT-AC B Complex (Mus musculus)
        
        ATAC A Complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        ATAC B Complex [nucleoplasm] (Mus musculus)
        
        ATAC A Complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - Formation of AT-AC C complex (Mus musculus)
        
        ATAC B Complex [nucleoplasm] (Mus musculus)
        
        ATAC A Complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        ATAC C Complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
- mRNA Capping (Mus musculus)
  - Activation of GT (Mus musculus)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - Capping complex formation (Mus musculus)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Capping complex (initial) [nucleoplasm] (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - Dissociation of transcript with 5'-GMP from GT (Mus musculus)
    - Capping complex (GpppN..) [nucleoplasm] (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - Formation of the CE:GMP intermediate complex (Mus musculus)
    - Capping complex (intermediate) [nucleoplasm] (Mus musculus)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Mus musculus)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Capping complex (hydrolyzed) [nucleoplasm] (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Mus musculus)
    - Capping complex (hydrolyzed) [nucleoplasm] (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Capping complex (initial) [nucleoplasm] (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Mus musculus)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Mus musculus)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Mus musculus)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Mus musculus)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Mus musculus)
    - Capping complex (intermediate) [nucleoplasm] (Mus musculus)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Mus musculus)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
    - Capping complex (GpppN..) [nucleoplasm] (Mus musculus)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Nuclear Receptors (Mus musculus)
  - ESR-mediated signaling (Mus musculus)
    - Estrogen-dependent gene expression (Mus musculus)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Mus musculus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by FGFR (Mus musculus)
    - Signaling by FGFR2 (Mus musculus)
      - FGFR2 alternative splicing (Mus musculus)
        
        PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Mus musculus)
        
        FGFR2 IIIc-specific splicing complex [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Mus musculus)
        
        RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Mus musculus)
        
        POLR2B [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CFI7 Polr2b

Gene Names

Polr2b

Chain

chain:1-1174

Reference Genes

BioGPS Gene:231329 Polr2b

KEGG:mmu:231329 Polr2b

Monarch:231329 Polr2b

NCBI Gene:231329 Polr2b

UCSC:Q8CFI7 Polr2b

Reference Transcript

RefSeq:NM_153798.2 Polr2b

Other Identifiers

10522716

1433552_a_at

17438496

231329

4324838

4374006

4457740

4585045

4689067

4692413

4764861

4771027

4771655

4831939

4832603

4849535

4879278

4920126

4934901

4965806

5008702

5010689

5012536

5214715

5233257

5240819

5257537

5359197

5413440

5421413

5431101

5456507

5479924

5513555

5557382

A_51_P509881

A_52_P486253

A_55_P2599302

GE137145

GO:0000428

GO:0000781

GO:0001172

GO:0003677

GO:0003682

GO:0003824

GO:0003899

GO:0003968

GO:0005634

GO:0005654

GO:0005665

GO:0006351

GO:0006366

GO:0008270

GO:0016740

GO:0016779

GO:0016787

GO:0032549

GO:0034062

GO:0046872

GO:0140098

ILMN_1245755

ILMN_2447512

Msa.33546.0_s_at

mMC008563

Participates

as a component of

Other forms of this molecule

RNA polymerase II subunit RPB2 [nucleoplasm]

Inferred From

POLR2B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_722493.2

ENSEMBL

ENSMUSP00000031167, ENSMUSG00000029250, ENSMUST00000031167

IntEnz

2.7.7.48

PRO

Q8CFI7

GlyGen

Q8CFI7

MGI

2388280

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