Reactome | Tp53bp1 [nucleoplasm]

Tp53bp1 [nucleoplasm]

Stable Identifier

R-MMU-61175

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

TP53BP1, P70399

Locations in the PathwayBrowser

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DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - DNA Double Strand Break Response (Mus musculus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
      - ATM phosphorylates TP53BP1 at DNA DSBs (Mus musculus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Mus musculus)
        
        Tp53bp1 [nucleoplasm] (Mus musculus)
      - PPP5C dephosphorylates TP53BP1 (Mus musculus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Mus musculus)
        
        Tp53bp1 [nucleoplasm] (Mus musculus)
      - TP53BP1 associates with H4K20Me2 at DNA DSBs (Mus musculus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Mus musculus)
        
        Tp53bp1 [nucleoplasm] (Mus musculus)
        
        Tp53bp1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P70399

Gene Names

Tp53bp1

Reference Genes

BioGPS Gene:27223 TP53BP1

CTD Gene:27223 TP53BP1

ENSEMBL:ENSMUSG00000043909

KEGG:mmu:27223 TP53BP1

Monarch:27223 TP53BP1

NCBI Gene:27223 TP53BP1

UCSC:P70399 TP53BP1

Reference Transcript

Participates

as an input of

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Mus musculus)

Other forms of this molecule

Tp53bp1 [nucleoplasm]

phospho-Tp53bp1 [nucleoplasm]

Inferred From

TP53BP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_038763.3, NP_001277759.1, XP_011237883.1

ENSEMBL

ENSMUSG00000043909, ENSMUSP00000106278, ENSMUST00000110648

PRO

P70399

GlyGen

P70399

MGI

1351320

PDB

1SSF

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6NZQ4 Paxip1	2	Paxip1 [nucleoplasm] (R-MMU-5619398) Paxip1 [nucleoplasm] (R-MMU-5619395)	0.463	3

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