Reactome | Itga2b [plasma membrane]

Itga2b [plasma membrane]

Stable Identifier

R-MMU-57578

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

ITGA2B(32-1039), Q9QUM0

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - L1CAM interactions (Mus musculus)
      - Signal transduction by L1 (Mus musculus)
        
        L1 interaction with Integrins (Mus musculus)
        
        Integrins [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        L1:Integrin complex [plasma membrane] (Mus musculus)
        
        Integrins [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)

Hemostasis (Mus musculus)

- Platelet activation, signaling and aggregation (Mus musculus)
  - Platelet Aggregation (Plug Formation) (Mus musculus)
    - Integrin signaling (Mus musculus)
      - Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Autophosphorylation of PTK2 at Y397 (Mus musculus)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Autophosphorylation of SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
        
        Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Recruitment of GRB2 to p-PTK2 (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Mus musculus)
        
        Integrin alpha IIb p(T779)-beta 3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3 activation (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Phosphorylation of pPTK2 by SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Release of CSK from SRC (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
        
        Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - SYK activation by SRC (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - SYK binds to integrin alphaIIb beta3 (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Translocation of PTK2 to Focal complexes (Mus musculus)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - p130Cas linkage to MAPK signaling for integrins (Mus musculus)
        
        Crk binding to p130cas (Mus musculus)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Recruitment of BCAR1 to PTK2 complex (Mus musculus)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Response to elevated platelet cytosolic Ca2+ (Mus musculus)
    - Platelet degranulation (Mus musculus)
      - Surface deployment of platelet alpha granule membrane components (Mus musculus)
        
        Platelet alpha granule membrane components that are released on degranulation [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Integrin signaling (Mus musculus)
  - Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Autophosphorylation of PTK2 at Y397 (Mus musculus)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Autophosphorylation of SRC (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
    - Focal complex [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
      - Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
    - Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Recruitment of GRB2 to p-PTK2 (Mus musculus)
      - GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Mus musculus)
    - Integrin alpha IIb p(T779)-beta 3 [plasma membrane] (Mus musculus)
      - Itga2b [plasma membrane] (Mus musculus)
    - Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
      - Itga2b [plasma membrane] (Mus musculus)
  - Integrin alphaIIb beta3 activation (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
      - Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
    - Focal complex [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Phosphorylation of pPTK2 by SRC (Mus musculus)
    - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Release of CSK from SRC (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:Inactive (p-Y530)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - SHC1 dissociates from integrin alphaIIb beta3 (Mus musculus)
    - Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - SYK activation by SRC (Mus musculus)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - SYK binds to integrin alphaIIb beta3 (Mus musculus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - Translocation of PTK2 to Focal complexes (Mus musculus)
    - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
      - Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
  - p130Cas linkage to MAPK signaling for integrins (Mus musculus)
    - Crk binding to p130cas (Mus musculus)
      - CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
    - Recruitment of BCAR1 to PTK2 complex (Mus musculus)
      - BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:Active (p-Y419)-SRC [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        Dissociation of RAS:RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        RAF phosphorylates MAP2K dimer (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
        
        RAF/MAPK scaffolds [cytosol] (Mus musculus)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
        
        Focal complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Mus musculus)
        
        Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Mus musculus)
        
        Integrin alpha2bbeta3 [plasma membrane] (Mus musculus)
        
        Itga2b [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QUM0

Gene Names

Itga2b

Reference Genes

BioGPS Gene:16399 Itga2b

ENSEMBL:ENSMUSG00000034664

KEGG Gene (Mus musculus):16399 Itga2b

Monarch:16399 Itga2b

NCBI Gene:16399 Itga2b

UCSC:Q9QUM0 Itga2b

Reference Transcript

RefSeq:NM_010575.2 Itga2b

Other Identifiers

10391697

131845_at

1417758_at

16399

17270222

4388794

4392912

4404779

4443623

4454841

4465781

4481968

4645494

4681578

4682153

4686783

4686819

4686948

4731232

4859737

4870776

4875452

4921081

4968373

4980529

5006374

5017270

5066816

5120539

5131819

5142948

5180933

5250710

5365532

5425846

5468582

5489926

5498186

5519411

5542467

5586737

A_52_P459564

GE35619

GO:0002376

GO:0002687

GO:0003674

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0005925

GO:0006950

GO:0007155

GO:0007160

GO:0007165

GO:0007229

GO:0008150

GO:0008305

GO:0009897

GO:0009986

GO:0016020

GO:0016021

GO:0032991

GO:0040011

GO:0042802

GO:0043167

GO:0043226

GO:0046872

GO:0048870

GO:0050840

GO:0070051

GO:0070062

GO:0070527

ILMN_2732623

ILMN_2911123

mMC023235

Participant Of

hasComponent

Other forms of this molecule

Itga2b [platelet alpha granule membrane]

Inferred From

ITGA2B(32-1039) [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_034705.2

Ensembl

ENSMUSG00000034664, ENSMUST00000103086, ENSMUSP00000099375

PRO

Q9QUM0

MGI

96601

Cite Us!