Ttf-I binds the T0 region (Sal Box) of the rDNA

Stable Identifier
R-MMU-573369
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Ttf-I binds the T0 region (Sal Box) of the rDNA
The Transcription termination factor (Ttf1, also known as Ttf-1 and Ttf-I) binds the Sal box element in the intergenic regions of rRNA genes (Grummt et al. 1986, Evers and Grummt 1995). Affinity of Ttf1 for Sal box DNA is about 0.1X the affinity of other transcription factors, such as the A and B isoforms of human MAX, for their binding sites (Diermeier et al. 2013). Ttf1 cooperatively binds Sal box chromatin and forms oligomers that organize rDNA repeats into loops (Diermeier et al. 2013). Ttf1 participates in pausing transcription and in epigenetic regulation of rRNA transcription (Diermeier et al. 2013). Interactions with other proteins such as Tip5 influence the DNA-binding activity of Ttf1 (Nemeth et al. 2004).
Literature References
PubMed ID Title Journal Year
3458534 A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination.

Grummt, I, Rosenbauer, H, Niedermeyer, I, Maier, U, Ohrlein, A

Cell 1986
7597036 Molecular coevolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-I.

Evers, R, Grummt, I

Proc Natl Acad Sci U S A 1995
24068958 Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites

Diermeier, SD, Németh, A, Rehli, M, Grummt, I, Längst, G

PLoS Genet. 2013
15292447 The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo

Németh, A, Strohner, R, Grummt, I, Längst, G

Nucleic Acids Res. 2004
18354495 Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes

Németh, A, Guibert, S, Tiwari, VK, Ohlsson, R, Längst, G

EMBO J 2008
Participants
Input
Output
Orthologous Events
TTF-I binds to the Sal Box (Homo sapiens)
Authored
May, B  (2010-04-06)
Reviewed
Shiao, YH  (2014-02-18)
Iben, S  (2016-02-12)
Created
May, B  (2010-04-10)
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