Reactome | Tgfa [ER to Golgi transport vesicle membrane]

Tgfa [ER to Golgi transport vesicle membrane]

Stable Identifier

R-MMU-5689840

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

ER to Golgi transport vesicle membrane

Synonyms

TGFA precursor, P48030

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPII-mediated vesicle transport (Mus musculus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CSNK1D phosphorylates SEC23 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Nucleotide exchange on RAB1 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPII-mediated vesicle transport (Mus musculus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
      - COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
      - CSNK1D phosphorylates SEC23 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
      - Nucleotide exchange on RAB1 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)
      - Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CNIH1:TFGA,AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Tgfa [ER to Golgi transport vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P48030

Gene Names

Tgfa

Reference Genes

BioGPS Gene:21802 Tgfa

ENSEMBL:ENSMUSG00000029999

KEGG:mmu:21802 Tgfa

Monarch:21802 Tgfa

NCBI Gene:21802 Tgfa

UCSC:P48030 Tgfa

Reference Transcript

RefSeq:NM_031199.4 Tgfa

Other Identifiers

10539692

1421942_s_at

1421943_at

1450421_at

167516_at

17460385

21802

4400755

4438761

4744849

4811574

4957671

4975581

5042881

5110252

5137720

5187230

5249558

5615123

92369_at

A_51_P415126

A_52_P555423

GE41601

GO:0001525

GO:0005154

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0007166

GO:0007173

GO:0008083

GO:0008284

GO:0009986

GO:0016020

GO:0016323

GO:0030297

GO:0031410

GO:0038127

GO:0038134

GO:0043066

GO:0043226

GO:0043410

GO:0045840

GO:0048018

GO:0048471

GO:0048856

GO:0050679

GO:0050731

GO:0051781

GO:0060749

GO:0072574

GO:0098772

ILMN_2765162

mMC012528

u65016_s_at

Participates

as a member of

TFGA, AREG precursors [ER to Golgi transport vesicle membrane] (Mus musculus)

Other forms of this molecule

Tgfa [clathrin-coated endocytic vesicle membrane]

Tgfa [endoplasmic reticulum-Golgi intermediate compartment membrane]

Tgfa [endoplasmic reticulum membrane]

Tgfa [extracellular region]

Inferred From

TGFA precursor [ER to Golgi transport vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_112476.1

ENSEMBL

ENSMUSP00000032066, ENSMUST00000032066

PRO

P48030

GlyGen

P48030

MGI

98724

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