Reactome | MCFD2 [endoplasmic reticulum membrane]

MCFD2 [endoplasmic reticulum membrane]

Stable Identifier

R-MMU-5689470

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

endoplasmic reticulum membrane

Synonyms

Q8K5B2

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPII-mediated vesicle transport (Mus musculus)
        
        Inner coat assembly and cargo binding (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        Loss of SAR1B GTPase (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        SEC31:SEC13 and v-SNARE recruitment (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        Cargo concentration in the ER (Mus musculus)
        
        Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        Inner coat assembly and cargo binding (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPII-mediated vesicle transport (Mus musculus)
      - Inner coat assembly and cargo binding (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
      - Loss of SAR1B GTPase (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
      - SEC31:SEC13 and v-SNARE recruitment (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
      - Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
    - Cargo concentration in the ER (Mus musculus)
      - Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
      - Inner coat assembly and cargo binding (Mus musculus)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Mus musculus)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Mus musculus)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)
        
        MCFD2 [endoplasmic reticulum membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8K5B2

Reference Genes

BioGPS Gene:193813

ENSEMBL:ENSMUSG00000024150

KEGG Gene (Mus musculus):193813

Monarch:193813

NCBI Gene:193813

UCSC:Q8K5B2

Reference Transcript

Other Identifiers

10453436

1424024_at

17347903

193813

4457190

4457366

4471007

4544953

4562518

4562779

4844791

5131328

5223989

5279950

5380992

5427160

5587611

97451_at

A_51_P465232

A_52_P350477

GE129437

GO:0003674

GO:0005509

GO:0005576

GO:0005622

GO:0005737

GO:0005783

GO:0005793

GO:0005794

GO:0015031

GO:0016192

GO:0019752

GO:0043226

GO:0046872

GO:0060548

ILMN_2479508

ILMN_2488749

ILMN_2677560

ILMN_2693772

ILMN_3111298

mMC015339

Participates

as a component of

hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Mus musculus)

Other forms of this molecule

MCFD2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

MCFD2 [ER to Golgi transport vesicle membrane]

Inferred From

MCFD2 [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

RefSeq

NP_789778.1, NP_647456.1, XP_006523964.1

Ensembl

ENSMUSP00000121820, ENSMUSG00000024150, ENSMUSP00000123352, ENSMUST00000144236, ENSMUST00000024963, ENSMUSP00000024963, ENSMUST00000129616

PRO

Q8K5B2

MGI

2183439

Cite Us!