Reactome | Clec6a [plasma membrane]

Clec6a [plasma membrane]

Stable Identifier

R-MMU-5621128

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

C-type lectin domain family 6 member A, CLC6A_MOUSE

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - C-type lectin receptors (CLRs) (Mus musculus)
    - Dectin-2 family (Mus musculus)
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
      - PLCG2 translocates from cytosol to plasma membrane (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
      - SYK autophosphorylates (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
      - SYK binds to p-Y65,Y76-FCER1G (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Mus musculus)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer:alpha-mannan [plasma membrane] (Mus musculus)
        
        CLEC6A:p-Y65,Y76-FCER1G dimer [plasma membrane] (Mus musculus)
        
        Clec6a [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9JKF4 Clec6a

Gene Names

Clec6a, Clec4n, Clecsf10, Dectin2

Chain

chain:1-209

Reference Genes

BioGPS Gene:56620 Clec6a

CTD Gene:56620 Clec6a

KEGG:mmu:56620 Clec6a

Monarch:56620 Clec6a

NCBI Gene:56620 Clec6a

UCSC:Q9JKF4 Clec6a

Reference Transcript

Other Identifiers

10541605

1419627_s_at

1425951_a_at

17462788

4375820

4700044

4761093

5021026

5060170

5265559

5281084

5285160

5327576

5385547

5423960

5485783

56620

A_51_P263471

A_55_P2035018

GE37652

GO:0001819

GO:0001878

GO:0001879

GO:0002223

GO:0002250

GO:0002376

GO:0005509

GO:0005515

GO:0005537

GO:0005886

GO:0009897

GO:0016020

GO:0030246

GO:0038187

GO:0043123

GO:0045087

GO:0046872

GO:0050832

GO:0061760

GO:0098542

GO:1902533

GO:2000318

ILMN_1216664

ILMN_2993314

mMC024925

Participates

as a component of

Other forms of this molecule

CLEC4C [ficolin-1-rich granule membrane]

CLEC4C [tertiary granule membrane]

CLEC4C [plasma membrane]

CLEC4C [secretory granule membrane]

Inferred From

CLEC6A [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_064385.1, NP_001177250.1

ENSEMBL

ENSMUSP00000024118, ENSMUSP00000108173, ENSMUST00000024118, ENSMUST00000112554, ENSMUSG00000023349

PRO

Q9JKF4

GlyGen

Q9JKF4

MGI

1861231

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