Mafb:Jun and Egr2 activate Hoxb3 expression

Stable Identifier
R-MMU-5619440
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mafb:Jun and Egr2 activate Hoxb3 expression
During embryogenesis the Mafb:Jun (Kreisler:Jun) heterodimer binds the rhombomere 5 (r5) enhancer located 5' to the P1 promoter of the Hoxb3 gene and activates expression in r5 (Manzanares et al. 1997, Manzanares et al. 1999, Manzanares et al. 2002, Yau et al. 2002, Mechta-Grigoriou et al. 2003). Egr2 (Krox20) also binds the r5 enhancer and is required to activate the Hoxb3 gene in r5 (Manzanares et al. 2002). After initial activation Hoxb3 is hypothesized to maintain its own expression (Yau et al. 2002). Hoxb3 is expressed most strongly in r5 and more weakly in caudal rhombomeres r6 and r7.
Literature References
PubMed ID Title Journal Year
12798298 c-jun regulation and function in the developing hindbrain

Mechta-Grigoriou, F, Giudicelli, F, Pujades, C, Charnay, P, Yaniv, M

Dev. Biol. 2003
12482716 Auto/cross-regulation of Hoxb3 expression in posterior hindbrain and spinal cord

Yau, TO, Kwan, CT, Jakt, LM, Stallwood, N, Cordes, S, Sham, MH

Dev. Biol. 2002
11823429 Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain

Manzanares, M, Nardelli, J, Gilardi-Hebenstreit, P, Marshall, H, Giudicelli, F, Martínez-Pastor, MT, Krumlauf, R, Charnay, P

EMBO J. 2002
9895323 Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes

Manzanares, M, Cordes, S, Ariza-McNaughton, L, Sadl, V, Maruthainar, K, Barsh, G, Krumlauf, R

Development 1999
Participants
Input
Output
Orthologous Events
MAFB:JUN and EGR2 activate HOXB3 expression (Homo sapiens)
Authored
May, B  (2014-08-16)
Rezsohazy, R  (2015-11-15)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-22)
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