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NLRP3 [cytosol]
Stable Identifier
R-MMU-561189
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q8R4B8
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Innate Immune System (Mus musculus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Mus musculus)
Inflammasomes (Mus musculus)
The NLRP3 inflammasome (Mus musculus)
NLRP3 activation by small molecules (Mus musculus)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Mus musculus)
NLRP3 [cytosol] (Mus musculus)
NLRP3:SUGT1:HSP90 [cytosol] (Mus musculus)
NLRP3 [cytosol] (Mus musculus)
SGT1:HSP90 binds inactive NLRP3 (Mus musculus)
NLRP3 [cytosol] (Mus musculus)
NLRP3:SUGT1:HSP90 [cytosol] (Mus musculus)
NLRP3 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Metalloprotease DUBs (Mus musculus)
BRISC complex deubiquitinates NLRP3 (Mus musculus)
BRISC complex:NLRP3 [cytosol] (Mus musculus)
NLRP3 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8R4B8 Nlrp3
Gene Names
Nlrp3, Cias1, Mmig1, Nalp3, Pypaf1
Chain
chain:1-1033
Reference Genes
BioGPS Gene:216799 Nlrp3
KEGG:mmu:216799 Nlrp3
Monarch:216799 Nlrp3
NCBI Gene:216799 Nlrp3
UCSC:Q8R4B8 Nlrp3
Reference Transcript
RefSeq:NM_001359638.1 Nlrp3
RefSeq:XM_036156549.1 Nlrp3
RefSeq:NM_145827.4 Nlrp3
RefSeq:XM_036156548.1 Nlrp3
RefSeq:XM_006532858.2 Nlrp3
Other Identifiers
10376513
140451_at
1425412_at
17250249
216799
4518494
4729464
4827760
4882378
4882965
4987401
5005529
5190402
5245551
5279348
5281784
5326107
5356259
5356263
5604013
A_52_P650540
A_55_P2273439
GE132420
GO:0000139
GO:0000166
GO:0002221
GO:0002376
GO:0002526
GO:0002720
GO:0002830
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005739
GO:0005783
GO:0005794
GO:0005815
GO:0005829
GO:0005856
GO:0006355
GO:0006954
GO:0007231
GO:0009595
GO:0009615
GO:0016020
GO:0016787
GO:0016887
GO:0031021
GO:0032731
GO:0032736
GO:0032753
GO:0032754
GO:0035591
GO:0043531
GO:0043565
GO:0044546
GO:0045087
GO:0045471
GO:0045630
GO:0045944
GO:0050727
GO:0050729
GO:0050830
GO:0051260
GO:0051607
GO:0060090
GO:0061702
GO:0065003
GO:0070269
GO:0070273
GO:0071222
GO:0071224
GO:0072559
GO:0098542
GO:0098772
GO:0140297
GO:0140299
GO:1901223
GO:1901981
GO:2000321
GO:2000553
ILMN_1237471
ILMN_2629297
ILMN_2716116
mMC010489
Participates
as a component of
BRISC complex:NLRP3 [cytosol] (Mus musculus)
NLRP3:SUGT1:HSP90 [cytosol] (Mus musculus)
NLRP3 elicitor small molecules:NLRP3 [cytosol] (Mus musculus)
as an input of
SGT1:HSP90 binds inactive NLRP3 (Mus musculus)
Other forms of this molecule
K63polyUb-NLRP3 [cytosol]
Nlrp3 [cytosol]
Inferred From
NLRP3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001346567.1
,
XP_036012441.1
,
NP_665826.1
,
XP_006532921.1
,
XP_036012442.1
ENSEMBL
ENSMUSP00000078440
,
ENSMUST00000101148
,
ENSMUST00000079476
,
ENSMUSG00000032691
,
ENSMUSP00000098707
PRO
Q8R4B8
MGI
2653833
PDB
7VTQ
,
7LFH
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9EPB4 Pycard
5
Pycard [secretory granule lumen]
(R-MMU-6800957)
Pycard [extracellular region]
(R-MMU-6806196)
Pycard [azurophil granule lumen]
(R-MMU-6798768)
Asc [cytosol]
(R-MMU-877391)
Pycard [cytosol]
(R-MMU-561191)
0.848
7
UniProt:Q03963
5
phospho-p-EIF2AK2 [nucleoplasm]
(R-MMU-9836332)
SUMO-EIF2AK2 [cytosol]
(R-MMU-9834829)
ISG15-EIF2AK2 [cytosol]
(R-MMU-9833968)
phospho-p-EIF2AK2 [cytosol]
(R-MMU-9833834)
EIF2AK2 [cytosol]
(R-MMU-168699)
0.524
3
UniProt:P29452 Casp1
6
Casp1 [cytosol]
(R-MMU-448680)
Casp1 [cytosol]
(R-MMU-448686)
Casp1 [cytosol]
(R-MMU-448704)
Casp1 [cytosol]
(R-MMU-448674)
Procaspase-1 [cytosol]
(R-MMU-877398)
Casp1 [cytosol]
(R-MMU-448692)
0.524
2
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