Complexed Piwil2 binds cleaved transposon RNA

Stable Identifier
R-MMU-5605213
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Complexed Piwil2 binds cleaved transposon RNA
RNA cleaved by Piwil2 (Mili) can be transferred to another molecule of Piwil2 (Aravin et al. 2007, Beyret et al. 2012). This is part of the "ping pong cycle" that generates further secondary piRNAs from a longer precursor.
Literature References
PubMed ID Title Journal Year
17446352 Developmentally regulated piRNA clusters implicate MILI in transposon control

Aravin, AA, Sachidanandam, R, Girard, A, Fejes-Toth, K, Hannon, GJ

Science 2007
22907665 piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism

Beyret, E, Liu, N, Lin, H

Cell Res. 2012
Participants
Input
Output
Orthologous Events
Complexed PIWIL2 binds cleaved transposon RNA (Homo sapiens)
Authored
May, B  (2014-06-29)
Reviewed
Saito, K  (2014-10-25)
Created
May, B  (2014-07-05)
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