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EXO1 [nucleoplasm]
Stable Identifier
R-MMU-5357514
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Q9QZ11
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle Checkpoints (Mus musculus)
G2/M Checkpoints (Mus musculus)
G2/M DNA damage checkpoint (Mus musculus)
ATR phosphorylates TP53 (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
Homology Directed Repair (Mus musculus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
HDR through Homologous Recombination (HRR) (Mus musculus)
D-loop extension by DNA polymerases (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Homologous DNA Pairing and Strand Exchange (Mus musculus)
CX3 complex binds D-loop structures (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
D-loop formation mediated by PALB2, BRCA2 and RAD51 (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Presynaptic phase of homologous DNA pairing and strand exchange (Mus musculus)
BCDX2 complex stabilizes RAD51 filament (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Resolution of D-Loop Structures (Mus musculus)
Resolution of D-loop Structures through Holliday Junction Intermediates (Mus musculus)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
FIGNL1 binds RAD51 (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:FIRRM:FIGNL1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Ligation of DNA and formation of Holliday structures following repair synthesis (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
MUS81:EME1,EME2 cleaves D-loop (Mus musculus)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Mus musculus)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
HDR through Single Strand Annealing (SSA) (Mus musculus)
Association of RAD51 with RAD52:DNA double-strand break ends (Mus musculus)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Association of RAD52 with the RPA complex at resected DNA DSBs (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
ERCC1:XPF cleaves flaps generated by SSA (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
RAD52 promotes single strand annealing at resected DNA DSBs (Mus musculus)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Processing of DNA double-strand break ends (Mus musculus)
ATR activation at DNA DSBs (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
ATR phosphorylates RPA2 (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Activation of CHEK1 at resected DNA DSBs (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Association of RPA complexes with ssDNA at resected DNA DSBs (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Binding of ATR:ATRIP to RPA at resected DNA DSBs (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
CHEK1 is recruited to resected DNA DSBs (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Mus musculus)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Mismatch Repair (Mus musculus)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Mus musculus)
EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Activity through Phosphorylation (Mus musculus)
ATR phosphorylates TP53 (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Mus musculus)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Mus musculus)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
EXO1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9QZ11
Reference Genes
BioGPS Gene:26909
ENSEMBL:ENSMUSG00000039748
KEGG:mmu:26909
Monarch:26909
NCBI Gene:26909
UCSC:Q9QZ11
Reference Transcript
RefSeq:NM_012012.4
RefSeq:XM_006496863.3
RefSeq:XM_006496862.3
Other Identifiers
10352048
1418026_at
1418027_at
1430225_at
17219848
26909
4382181
4501739
4575517
4619679
4659077
4783204
4842125
4907819
4974380
5010944
5061634
5087537
5167148
5183267
5274621
5344198
5345471
5345870
5360169
5401359
5404406
5415128
5523333
5586756
92244_at
A_51_P239984
GE35371
GO:0002376
GO:0002455
GO:0003677
GO:0003682
GO:0003824
GO:0004518
GO:0004519
GO:0004527
GO:0005634
GO:0005654
GO:0005886
GO:0006139
GO:0006281
GO:0006298
GO:0006310
GO:0008409
GO:0016446
GO:0016604
GO:0016787
GO:0016788
GO:0017108
GO:0022414
GO:0035312
GO:0043226
GO:0045145
GO:0045190
GO:0046872
GO:0048256
GO:0051321
GO:0051908
GO:0110025
GO:0140097
ILMN_1216776
ILMN_1234323
ILMN_2611996
ILMN_2662763
ILMN_2873522
mMC000955
mMC005122
mMC009042
Participates
as an input of
EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) (Mus musculus)
as a component of
EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] (Mus musculus)
EXO1:BLM,WRN [nucleoplasm] (Mus musculus)
Inferred From
EXO1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006496925.1
,
XP_006496926.1
,
NP_036142.2
ENSEMBL
ENSMUST00000039725
,
ENSMUSG00000039748
,
ENSMUSP00000039376
PRO
Q9QZ11
MGI
1349427
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