Reactome | Mbd3 [nucleoplasm]

Mbd3 [nucleoplasm]

Stable Identifier

R-MMU-4657010

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

MBD3, Q9Z2D8

Locations in the PathwayBrowser

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Chromatin organization (Mus musculus)

- ATP-dependent chromatin remodelers (Mus musculus)
  - CHD chromatin remodelers (Mus musculus)
    - CHD3, CHD4, CHD5 subfamily (Mus musculus)
      - NuRD complex assembly (Mus musculus)
        
        CHD and CDK2AP subunits are recruited to NuRD (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        Interaction of NuRD complexes with transcription factors (Mus musculus)
        
        GATAD2A NuRD binds ZMYND8:ZNF532:ZNF592:ZNF687 (Mus musculus)
        
        GATAD2A NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4, RBBP7:MBD2,MBD3:GATAD2A [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        ZMYND8:ZNF532:ZNF592:ZNF687:GATAD2A NuRD [nucleoplasm] (Mus musculus)
        
        GATAD2A NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4, RBBP7:MBD2,MBD3:GATAD2A [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        NuRD binds Ikaros family member proteins (Mus musculus)
        
        IKZF1,IKZF2,IKZF3:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        NuRD deacetylates telomeric nucleosomes (Mus musculus)
        
        NR2C2,NR2F2:ZNF827:NuRD:H4K5,H4K8 Ac telomeric chromatin [nucleoplasm] (Mus musculus)
        
        NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        NR2C2,NR2F2:ZNF827:NuRD:telomeric chromatin [nucleoplasm] (Mus musculus)
        
        NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        PHF6 binds NuRD (Mus musculus)
        
        NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        PHF6:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD [nucleoplasm] (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        MBD2, MBD3 and GATAD2A, GATAD2B bind core NuRD complex (Mus musculus)
        
        HDAC1, HDAC2:MTA1, MTA2, MTA3:RBBP4, RBBP7:MBD2, MBD3:GATAD2A, GATAD2B [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        MBD2,MBD3 [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        MBD3L2 binds MBD3 NuRD core complex (Mus musculus)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4,BBP7:MBD3:GATAD2A,GATAD2B [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        MBD3L2:HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4,RBBP7:MBD3:GATAD2A,GATAD2B [nucleoplasm] (Mus musculus)
        
        HDAC1,HDAC2:MTA1,MTA2,MTA3:RBBP4,BBP7:MBD3:GATAD2A,GATAD2B [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
- Chromatin modifying enzymes (Mus musculus)
  - HDACs deacetylate histones (Mus musculus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Mus musculus)
      - HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Mus musculus)
        
        HDAC1:2-containing complex [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase I Transcription (Mus musculus)
  - RNA Polymerase I Promoter Clearance (Mus musculus)
    - RNA Polymerase I Transcription Initiation (Mus musculus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Mus musculus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - Regulation of TP53 Activity (Mus musculus)
        
        Regulation of TP53 Activity through Acetylation (Mus musculus)
        
        MTA2-NuRD complex deacetylates TP53 (Mus musculus)
        
        MTA2-NuRD complex [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        SALL4 recruits NuRD to PTEN gene (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Mus musculus)
        
        SALL4:NuRD [nucleoplasm] (Mus musculus)
        
        NuRD complex [nucleoplasm] (Mus musculus)
        
        Mbd3 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9Z2D8 Mbd3

Gene Names

Mbd3

Chain

chain:1-285

Reference Genes

BioGPS Gene:17192 MBD3

KEGG:mmu:17192 MBD3

Monarch:17192 MBD3

NCBI Gene:17192 MBD3

UCSC:Q9Z2D8 MBD3

Reference Transcript

Participates

as a component of

as a member of

MBD2,MBD3 [nucleoplasm] (Mus musculus)

Other forms of this molecule

Mbd3 [nucleoplasm]

Inferred From

MBD3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_038623.1, NP_001293072.1

ENSEMBL

ENSMUSG00000035478, ENSMUST00000105349, ENSMUSP00000089948, ENSMUST00000092295, ENSMUSP00000100986

PRO

Q9Z2D8

MGI

1333812

HMDB Protein

HMDBP12761

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14404 Mecom	3	Mecom [nucleoplasm] (R-MMU-9830485) Mecom [cytosol] (R-MMU-5634790) Mecom [nucleoplasm] (R-MMU-8943897)	0.565	4

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