Sumoylation of Aurka with Sumo1

Stable Identifier
R-MMU-4655356
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sumoylation of Aurka with Sumo1
Aurka is sumoylated at lysine-249 with Sumo1 (Malumbres et al. 2011). Sumo1, Aurka, and Ube2i (Ubc9) are observed together at centrisomes and the mitotic spindle. Sumoylation is required for proper localization to microtubules of the spindle therefore sumoylated Aurka is assumed to be present on spindles in the cytosol during metphase.
Literature References
PubMed ID Title Journal Year
22649767 A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis

Pérez De Castro, I, Aguirre-Portolés, C, Martin, B, Fernández-Miranda, G, Klotzbucher, A, Kubbutat, MH, Megías, D, Arlot-Bonnemains, Y, Malumbres, M

Front Oncol 2011
Participants
Input
Output
Orthologous Events
SUMOylation of AURKA with SUMO1 (Homo sapiens)
Authored
May, B  (2013-09-28)
Reviewed
Zhang, XD  (2015-10-04)
Created
May, B  (2013-10-03)
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