Dscam binds Netrin-1

Stable Identifier
R-MMU-451348
Type
Reaction [binding]
Species
Mus musculus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dscam binds Netrin-1
DSCAM binds netrin-1 and directs the turning of axons towards netrin-1 source independent of DCC or cooperatively depending on the cellular and developmental context. Signaling mechanisms activated by netrin-1 downstream of DSCAM involve phosphorylation of Fyn and PAK1.
Literature References
PubMed ID Title Journal Year
19196994 DSCAM functions as a netrin receptor in commissural axon pathfinding

Liu, G, Li, W, Wang, L, Kar, A, Guan, KL, Rao, Y, Wu, JY

Proc Natl Acad Sci U S A 2009
18585357 DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1

Ly, A, Nikolaev, A, Suresh, G, Zheng, Y, Tessier-Lavigne, M, Stein, E

Cell 2008
18948420 Dscam guides embryonic axons by Netrin-dependent and -independent functions

Andrews, GL, Tanglao, S, Farmer, WT, Morin, S, Brotman, S, Berberoglu, MA, Price, H, Fernandez, GC, Mastick, GS, Charron, F, Kidd, T

Development 2008
Participants
Input
Output
Orthologous Events
DSCAM binds Netrin-1 (Homo sapiens)
Authored
Garapati, P V  (2010-01-05)
Reviewed
Clemens, JC  (2010-08-10)
Created
Garapati, P V  (2010-01-05)
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