CHL1 interacts with Hsc70

Stable Identifier
R-MMU-445075
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CHL1 interacts with Hsc70
CHL1 accumulates in the presynaptic plasma membrane and it recruits heat shock cognate 71 kDa protein (HSP7C/HSC70), in an ADP dependent manner. HSC70 interacts with the intracellular domain of CHL1. Upon synapse activation, CHL1 along with HSC70 is endocytosed and is targeted to synaptic vesicles (SVs). In synapses, HSC70 regulates uncoating of synaptic vesicles (SVs) in the clathrin-dependent recycling pathway (Leshchyns'ka et al. 2006, Zinsmaier & Bronk 2001).
Literature References
PubMed ID Title Journal Year
17178404 The adhesion molecule CHL1 regulates uncoating of clathrin-coated synaptic vesicles

Leshchyns'ka, I, Andreyeva, A, Richter, M, Sytnyk, V, Schachner, M, Puchkov, D

Neuron 2006
Participants
Input
Output
Orthologous Events
CHL1 interacts with HSP7C (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
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