Interaction of L1 with Neurocan

Stable Identifier
R-MMU-443770
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Interaction of L1 with Neurocan
L1CAM binds with high affinity to the proteoglycan neurocan. Neurocan binds to the first Ig domain of L1CAM through its sushi module and a chondroitin sulphate chain. This interaction interferes with the homophilic interaction of L1CAM and inhibits neuronal adhesion and neurite extension mediated by L1CAM.
Literature References
PubMed ID Title Journal Year
7513709 The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth

Margolis, RK, Grumet, M, Milev, P, Margolis, RU, Karthikeyan, L, Friedlander, DR

J Cell Biol 1994
10934197 Characterization of the L1-neurocan-binding site. Implications for L1-L1 homophilic binding

Gutwein, P, Rauch, U, Oleszewski, M, Altevogt, P, von der Lieth, W

J Biol Chem 2000
Participants
Input
Output
Entity On Other Cell
Orthologous Events
Interaction of L1 with Neurocan (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-12)
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