Reactome | SLC2A8 [plasma membrane]

SLC2A8 [plasma membrane]

Stable Identifier

R-MMU-429140

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

Q9JIF3

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - Clathrin-mediated endocytosis (Mus musculus)
    - BAR domain proteins recruit dynamin (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Mus musculus)
      - CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
    - Cargo recognition for clathrin-mediated endocytosis (Mus musculus)
      - AP-2 directly binds some endocytic cargo (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
    - Clathrin recruits PIK3C2A (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Mus musculus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        CLASP proteins:cargo [plasma membrane] (Mus musculus)
        
        AP-2:cargo [plasma membrane] (Mus musculus)
        
        AP-2 cargo [plasma membrane] (Mus musculus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Mus musculus)
        
        SLC2A8 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9JIF3

Reference Genes

BioGPS Gene:56017

ENSEMBL:ENSMUSG00000026791

ENSEMBL:ENSMUSG00000026791.15

KEGG Gene (Mus musculus):56017

Monarch:56017

NCBI Gene:56017

UCSC:Q9JIF3

Reference Transcript

RefSeq:NM_019488.4

Other Identifiers

101397_at

10481759

1450628_at

17384082

4335162

4372740

4655951

4780781

5009137

5060903

5062745

5077170

5146349

5280440

5284955

5354875

5406496

5537137

56017

A_51_P358171

A_52_P125354

A_55_P2081865

GE37381

GO:0001666

GO:0005215

GO:0005353

GO:0005354

GO:0005355

GO:0005536

GO:0005886

GO:0005975

GO:0006006

GO:0008021

GO:0008286

GO:0008643

GO:0015284

GO:0015755

GO:0015757

GO:0016020

GO:0022857

GO:0023052

GO:0030659

GO:0031410

GO:0033300

GO:0043226

GO:0055085

GO:0070837

GO:1904659

ILMN_1213148

ILMN_2664819

ILMN_2696642

aa254369_s_at

mMC025221

Participates

as a member of

Other forms of this molecule

SLC2A8 [clathrin-coated endocytic vesicle membrane]

Inferred From

SLC2A8 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_062361.1

Ensembl

ENSMUSP00000028129, ENSMUST00000028129, ENSMUSG00000026791

PRO

Q9JIF3

MGI

1860103

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