Reactome | Spta1 [cytosol]

Spta1 [cytosol]

Stable Identifier

R-MMU-391563

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

SPTA1, P08032

Locations in the PathwayBrowser

Expand all

Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - L1CAM interactions (Mus musculus)
      - Interaction between L1 and Ankyrins (Mus musculus)
        
        L1 linked to actin cytoskeleton by ankyrin (Mus musculus)
        
        L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Mus musculus)
        
        SPTA:SPTB:F-actin [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        SPTA:SPTB:F-actin [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
    - NCAM signaling for neurite out-growth (Mus musculus)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
      - Recruitment of Grb2 to pFAK:NCAM1 (Mus musculus)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Mus musculus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
      - SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPI-mediated anterograde transport (Mus musculus)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        ARFGAPs stimulate ARF GTPase activity (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        COPI vesicle uncoating (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - RAS GEFs promote RAS nucleotide exchange (Mus musculus)
        
        RAS GEFs [plasma membrane] (Mus musculus)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPI-mediated anterograde transport (Mus musculus)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
      - ARFGAPs stimulate ARF GTPase activity (Mus musculus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
      - COPI vesicle uncoating (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Mus musculus)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Mus musculus)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Mus musculus)
        
        Spectrin tetramer [cytosol] (Mus musculus)
        
        SPTA:SPTB [cytosol] (Mus musculus)
        
        Spectrin alpha chain [cytosol] (Mus musculus)
        
        Spta1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P08032

Gene Names

Spta1

Reference Genes

BioGPS Gene:20739 Spta1

ENSEMBL:ENSMUSG00000026532

KEGG:mmu:20739 Spta1

Monarch:20739 Spta1

NCBI Gene:20739 Spta1

UCSC:P08032 Spta1

Reference Transcript

RefSeq:NM_011465.4 Spta1

Other Identifiers

10351905

103941_at

1421277_at

1421278_s_at

17219698

20739

4312094

4337817

4368553

4375858

4399086

4403724

4425477

4453545

4459278

4461230

4482477

4514840

4551747

4577102

4706139

4715528

4845283

4852751

4868195

4881642

4905157

4934247

4949996

4960738

4963008

4967529

5001470

5049350

5054093

5140638

5144376

5150405

5199058

5228837

5267503

5305002

5310466

5330551

5349962

5354575

5359871

5364297

5370583

5425029

5458233

5458489

5463678

5492301

5501829

5506922

5547670

5591694

A_51_P501069

A_55_P2050508

GE119350

GO:0002260

GO:0002376

GO:0003779

GO:0005509

GO:0005515

GO:0005737

GO:0005856

GO:0005886

GO:0005938

GO:0006779

GO:0007009

GO:0008091

GO:0008092

GO:0008360

GO:0009898

GO:0014731

GO:0016020

GO:0030036

GO:0030054

GO:0030097

GO:0030424

GO:0030863

GO:0030864

GO:0032437

GO:0042102

GO:0042995

GO:0046872

GO:0048856

GO:0051015

GO:0051693

GO:0061024

ILMN_2662527

U87455_s_at

mMC005177

Participates

as a member of

Spectrin alpha chain [cytosol] (Mus musculus)

Inferred From

SPTA1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_035595.2

ENSEMBL

ENSMUSP00000027817, ENSMUST00000027817, ENSMUSG00000026532

PRO

P08032

GlyGen

P08032

MGI

98385

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