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Vhl [cytosol]
Stable Identifier
R-MMU-391423
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
VHL, P40338
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Mus musculus)
Vhl [cytosol] (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Proteasome proteolyzes ub-HIF-alpha (Mus musculus)
VBC complex (with or without LIMD1) [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Mus musculus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
26S proteasome degrades HIFalpha (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
VBC complex [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
RHOBTB3 ATPase cycle (Mus musculus)
RHOBTB3 binds interacting proteins at trans-Golgi network (Mus musculus)
RHOBTB3 interacting proteins [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Mus musculus)
RHOBTB3 interacting proteins [cytosol] (Mus musculus)
Vhl [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P40338
Gene Names
Vhl
Reference Genes
BioGPS Gene:22346 Vhl
ENSEMBL:ENSMUSG00000033933
KEGG:mmu:22346 Vhl
Monarch:22346 Vhl
NCBI Gene:22346 Vhl
UCSC:P40338 Vhl
Reference Transcript
RefSeq:NM_009507.3 Vhl
Other Identifiers
102676_at
10540790
106085_at
112888_at
140554_r_at
1421071_at
1434708_at
165334_s_at
17461798
22346
4341445
4392297
4394116
4556997
4637854
4861273
5045715
5076211
5147168
5181692
5410580
A_66_P106593
GE33888
GO:0000122
GO:0001525
GO:0001666
GO:0003309
GO:0003310
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005783
GO:0005886
GO:0005929
GO:0006355
GO:0006582
GO:0010468
GO:0010498
GO:0010629
GO:0014069
GO:0015031
GO:0016567
GO:0030154
GO:0030163
GO:0030182
GO:0030198
GO:0030891
GO:0031462
GO:0032880
GO:0042069
GO:0043161
GO:0043226
GO:0043534
GO:0044877
GO:0045446
GO:0045471
GO:0045602
GO:0048069
GO:0048593
GO:0048870
GO:0048877
GO:0050679
GO:0060090
GO:0061072
GO:0061073
GO:0070243
GO:0070244
GO:0097411
GO:0098978
GO:0099175
GO:0140252
GO:1902072
GO:1904262
GO:1990756
GO:2001233
ILMN_2518546
U12570_s_at
mMC013204
Participates
as a member of
RHOBTB3 interacting proteins [cytosol] (Mus musculus)
CUL2-box protein [cytosol] (Mus musculus)
as a component of
VBC complex [cytosol] (Mus musculus)
Other forms of this molecule
Vhl [nucleoplasm]
Vhl [nucleoplasm]
Inferred From
VHL [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSMUSP00000039418
,
ENSMUSG00000033933
,
ENSMUST00000035673
PRO
P40338
MGI
103223
PDB
1HV2
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