Reactome | DRD4 [plasma membrane]

DRD4 [plasma membrane]

Stable Identifier

R-MMU-390809

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

plasma membrane

Synonyms

P51436

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        DRD3,4:DA [plasma membrane] (Mus musculus)
        
        DRD3,4 [plasma membrane] (Mus musculus)
        
        DRD4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        DRD3,4:DA [plasma membrane] (Mus musculus)
        
        DRD3,4 [plasma membrane] (Mus musculus)
        
        DRD4 [plasma membrane] (Mus musculus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        DRD3,4:DA [plasma membrane] (Mus musculus)
        
        DRD3,4 [plasma membrane] (Mus musculus)
        
        DRD4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        DRD3,4:DA [plasma membrane] (Mus musculus)
        
        DRD3,4 [plasma membrane] (Mus musculus)
        
        DRD4 [plasma membrane] (Mus musculus)
      - The Ligand:GPCR:Gi complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        DRD3,4:DA [plasma membrane] (Mus musculus)
        
        DRD3,4 [plasma membrane] (Mus musculus)
        
        DRD4 [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        DRD3,4:DA [plasma membrane] (Mus musculus)
        
        DRD3,4 [plasma membrane] (Mus musculus)
        
        DRD4 [plasma membrane] (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Amine ligand-binding receptors (Mus musculus)
        
        Dopamine receptors (Mus musculus)
        
        D2D3,4 bind to DA (Mus musculus)
        
        DRD3,4 [plasma membrane] (Mus musculus)
        
        DRD4 [plasma membrane] (Mus musculus)
        
        DRD3,4:DA [plasma membrane] (Mus musculus)
        
        DRD3,4 [plasma membrane] (Mus musculus)
        
        DRD4 [plasma membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P51436

Reference Genes

BioGPS Gene:13491

ENSEMBL:ENSMUSG00000025496

ENSEMBL:ENSMUSG00000025496.6

KEGG Gene (Mus musculus):13491

Monarch:13491

NCBI Gene:13491

UCSC:P51436

Reference Transcript

RefSeq:NM_007878.2

Other Identifiers

10558866

13491

1422829_at

1422830_s_at

17484832

4341547

4367508

4386924

4429740

4512963

4575702

4714223

4783748

5128943

5170751

5197585

5241330

5281021

5527119

97755_at

A_51_P283499

A_52_P196278

A_66_P126290

GE34969

GO:0001591

GO:0001662

GO:0001963

GO:0001975

GO:0004930

GO:0004952

GO:0004993

GO:0005813

GO:0005815

GO:0005856

GO:0005886

GO:0005938

GO:0007165

GO:0007186

GO:0007187

GO:0007188

GO:0007195

GO:0007198

GO:0007212

GO:0007268

GO:0007610

GO:0007614

GO:0008306

GO:0008344

GO:0008355

GO:0016020

GO:0016192

GO:0017124

GO:0022414

GO:0023052

GO:0030424

GO:0030425

GO:0030594

GO:0034776

GO:0035240

GO:0042053

GO:0042220

GO:0042596

GO:0042734

GO:0042752

GO:0042802

GO:0043025

GO:0043195

GO:0043197

GO:0043226

GO:0043679

GO:0045211

GO:0046872

GO:0046928

GO:0048148

GO:0048511

GO:0048870

GO:0050482

GO:0050709

GO:0050805

GO:0050848

GO:0050877

GO:0051378

GO:0051379

GO:0051380

GO:0060080

GO:0060089

GO:0060406

GO:0065008

GO:0098978

GO:0098982

GO:0099072

GO:0099149

GO:0099171

GO:1901363

GO:1904706

GO:1904753

GO:2000463

ILMN_1217098

ILMN_2427989

Msa.1520.0_at

mMC006652

mMR030253

Participates

as a member of

DRD3,4 [plasma membrane] (Mus musculus)

Inferred From

DRD4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_031904.1

Ensembl

ENSMUST00000026569, ENSMUSG00000025496, ENSMUSP00000026569

PRO

P51436

MGI

94926

PDB

6IQL

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