Reactome | Cep57 [cytosol]

Cep57 [cytosol]

Stable Identifier

R-MMU-380271

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CEP57, Q8CEE0

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Mus musculus)

- Cilium Assembly (Mus musculus)
  - Assembly of the 9+0 primary cilium (Mus musculus)
    - Anchoring of the basal body to the plasma membrane (Mus musculus)
      - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - C2CD3 binds the mother centriole (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
        
        basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - CP110 and CEP97 dissociate from the centriole (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
        
        centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - MARK4 binds ODF2 in the centriole (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
        
        centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)
        
        basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - Recruitment of transition zone proteins (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - The distal appendage proteins recruit TTBK2 (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CEE0

Gene Names

Cep57

Reference Genes

BioGPS Gene:74360 Cep57

ENSEMBL:ENSMUSG00000031922

KEGG:mmu:74360 Cep57

Monarch:74360 Cep57

NCBI Gene:74360 Cep57

UCSC:Q8CEE0 Cep57

Reference Transcript

Other Identifiers

10590892

138562_at

1428968_at

1452983_at

162805_f_at

167957_at

17523994

4354965

4431967

4629722

4632173

4657563

4660198

4663957

4666573

4793037

4844964

4911263

4937672

4989279

5032762

5034582

5037634

5189515

5196536

5212752

5291216

5311737

5324593

5332843

5345278

5487121

5500780

5514122

5553881

5568977

5596387

74360

A_51_P281246

A_52_P1045123

A_55_P2595337

GE122661

GO:0005515

GO:0005634

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0007286

GO:0008017

GO:0008092

GO:0008543

GO:0017134

GO:0022414

GO:0034451

GO:0042802

GO:0042803

GO:0043015

GO:0048856

GO:0051260

GO:0065003

ILMN_1223812

ILMN_2727967

mMC012680

Participates

as a component of

Inferred From

CEP57 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_030100541.1, NP_001297650.1, NP_080941.3, XP_006510712.1

ENSEMBL

ENSMUSP00000034398, ENSMUST00000124883, ENSMUSP00000119081, ENSMUST00000034398, ENSMUSG00000031922, ENSMUSP00000114665, ENSMUST00000148086

PRO

Q8CEE0

MGI

1915551

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