Reactome | Cep57 [cytosol]

Cep57 [cytosol]

Stable Identifier

R-MMU-380271

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CEP57, Q8CEE0

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Mus musculus)

- Cilium Assembly (Mus musculus)
  - Anchoring of the basal body to the plasma membrane (Mus musculus)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
    - C2CD3 binds the mother centriole (Mus musculus)
      - mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Mus musculus)
      - basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
    - CP110 and CEP97 dissociate from the centriole (Mus musculus)
      - basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
    - MARK4 binds ODF2 in the centriole (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Mus musculus)
        
        basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
    - Recruitment of transition zone proteins (Mus musculus)
      - basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - basal body:transition zone proteins [cytosol] (Mus musculus)
        
        basal body [cytosol] (Mus musculus)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
    - The distal appendage proteins recruit TTBK2 (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Mus musculus)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Mus musculus)
        
        mother centriole:C2CD3 [cytosol] (Mus musculus)
        
        mother centriole [cytosol] (Mus musculus)
        
        Cep57 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CEE0

Gene Names

Cep57

Reference Genes

BioGPS Gene:74360 Cep57

ENSEMBL:ENSMUSG00000031922

ENSEMBL:ENSMUSG00000031922.13 Cep57

KEGG Gene (Mus musculus):74360 Cep57

Monarch:74360 Cep57

NCBI Gene:74360 Cep57

UCSC:Q8CEE0 Cep57

Reference Transcript

Other Identifiers

10590892

138562_at

1428968_at

1452983_at

162805_f_at

167957_at

17523994

4354965

4431967

4629722

4632173

4657563

4660198

4663957

4793037

4844964

4911263

5034582

5037634

5189515

5291216

5311737

5324593

5332843

5345278

5487121

5500780

5553881

5568977

5596387

74360

A_51_P281246

A_55_P2595337

GE122661

GO:0005515

GO:0005634

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0007286

GO:0008017

GO:0008092

GO:0008543

GO:0017134

GO:0022414

GO:0023052

GO:0030154

GO:0034451

GO:0042802

GO:0042803

GO:0043015

GO:0043226

GO:0048856

GO:0051260

GO:0065003

ILMN_1223812

ILMN_2727967

mMC012680

Participates

as a component of

Inferred From

CEP57 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006510712.1, NP_080941.3, NP_001297650.1

Ensembl

ENSMUST00000148086, ENSMUSP00000114665, ENSMUST00000034398, ENSMUSP00000119081, ENSMUSP00000034398, ENSMUSG00000031922, ENSMUST00000124883

PRO

Q8CEE0

MGI

1915551

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